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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TTC1
All Species:
43.64
Human Site:
S281
Identified Species:
68.57
UniProt:
Q99614
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99614
NP_003305.1
292
33526
S281
D
S
S
T
G
S
Y
S
I
N
F
V
Q
N
P
Chimpanzee
Pan troglodytes
XP_001141156
292
33408
S281
D
S
S
T
G
S
Y
S
I
N
F
V
Q
N
P
Rhesus Macaque
Macaca mulatta
XP_001083639
292
33646
S281
D
S
S
T
G
S
Y
S
I
N
F
V
Q
N
P
Dog
Lupus familis
XP_546270
293
33698
S282
D
S
S
T
G
S
Y
S
I
N
F
V
Q
N
P
Cat
Felis silvestris
Mouse
Mus musculus
Q91Z38
292
33244
S281
D
S
S
T
G
S
Y
S
I
N
F
V
Q
N
P
Rat
Rattus norvegicus
NP_001005529
292
33291
S281
D
S
S
T
G
S
Y
S
I
N
F
V
Q
N
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506286
295
33897
S283
D
S
S
T
G
S
Y
S
I
N
F
V
Q
N
P
Chicken
Gallus gallus
XP_414484
343
39127
S332
D
S
S
T
G
S
Y
S
I
N
F
V
Q
N
P
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001007383
319
36919
S307
D
T
N
T
G
S
Y
S
I
N
F
V
Q
N
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650543
263
29383
Q248
G
L
S
T
Q
N
F
Q
M
Q
Q
D
P
N
T
Honey Bee
Apis mellifera
XP_623446
277
32061
S269
D
P
N
S
G
G
Y
S
V
K
F
H
Q
N
P
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_782508
374
41657
S359
D
P
N
S
G
S
Y
S
M
N
F
Q
Q
N
P
Poplar Tree
Populus trichocarpa
XP_002324511
278
30733
G255
N
T
L
L
G
R
F
G
M
S
V
D
N
F
K
Maize
Zea mays
NP_001136906
255
27711
K239
G
M
S
V
D
N
F
K
A
V
K
D
P
N
T
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_194777
277
30908
E244
E
A
I
T
K
L
K
E
M
G
N
S
I
L
G
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
97.5
87.7
N.A.
83.5
83.9
N.A.
72.5
59.1
N.A.
52.3
N.A.
42.8
44.5
N.A.
38.7
Protein Similarity:
100
99.6
98.6
93.1
N.A.
90.7
91.7
N.A.
84.4
72.5
N.A.
70.8
N.A.
60.9
64
N.A.
57.7
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
100
100
N.A.
86.6
N.A.
20
53.3
N.A.
66.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
N.A.
100
N.A.
40
73.3
N.A.
86.6
Percent
Protein Identity:
35.2
32.5
N.A.
34.2
N.A.
N.A.
Protein Similarity:
50.6
50.6
N.A.
55.1
N.A.
N.A.
P-Site Identity:
6.6
13.3
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
40
26.6
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
0
0
0
0
0
7
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
74
0
0
0
7
0
0
0
0
0
0
20
0
0
0
% D
% Glu:
7
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
20
0
0
0
74
0
0
7
0
% F
% Gly:
14
0
0
0
80
7
0
7
0
7
0
0
0
0
7
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% H
% Ile:
0
0
7
0
0
0
0
0
60
0
0
0
7
0
0
% I
% Lys:
0
0
0
0
7
0
7
7
0
7
7
0
0
0
7
% K
% Leu:
0
7
7
7
0
7
0
0
0
0
0
0
0
7
0
% L
% Met:
0
7
0
0
0
0
0
0
27
0
0
0
0
0
0
% M
% Asn:
7
0
20
0
0
14
0
0
0
67
7
0
7
87
0
% N
% Pro:
0
14
0
0
0
0
0
0
0
0
0
0
14
0
74
% P
% Gln:
0
0
0
0
7
0
0
7
0
7
7
7
74
0
0
% Q
% Arg:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
54
67
14
0
67
0
74
0
7
0
7
0
0
0
% S
% Thr:
0
14
0
74
0
0
0
0
0
0
0
0
0
0
14
% T
% Val:
0
0
0
7
0
0
0
0
7
7
7
60
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
74
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _