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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TTC1 All Species: 36.67
Human Site: Y132 Identified Species: 57.62
UniProt: Q99614 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q99614 NP_003305.1 292 33526 Y132 E Q F K K G D Y I E A E S S Y
Chimpanzee Pan troglodytes XP_001141156 292 33408 Y132 E Q F K K G D Y I E A E S S Y
Rhesus Macaque Macaca mulatta XP_001083639 292 33646 Y132 E Q F K K G D Y I E A E S S Y
Dog Lupus familis XP_546270 293 33698 Y133 V Q F K K G D Y I E A E S S Y
Cat Felis silvestris
Mouse Mus musculus Q91Z38 292 33244 Y132 E R F K R G D Y M E A E S S Y
Rat Rattus norvegicus NP_001005529 292 33291 Y132 E Q F K R G D Y V E A E S S Y
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506286 295 33897 Y134 E Q F K K G E Y T E A E S S Y
Chicken Gallus gallus XP_414484 343 39127 Y183 E Q F K K G D Y G E A E D S Y
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001007383 319 36919 H158 A Q F K S G E H V E A E E S Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_650543 263 29383 S129 D I C P S A S S K E R A V L Y
Honey Bee Apis mellifera XP_623446 277 32061 Y120 D L F K R E E Y L E A I S V Y
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_782508 374 41657 F210 N L F K Q D E F L D A I S S Y
Poplar Tree Populus trichocarpa XP_002324511 278 30733 Y121 R L F G N G Q Y E E A L L Q Y
Maize Zea mays NP_001136906 255 27711 R123 L E S S E D I R A A C H S N R
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_194777 277 30908 E123 F V N G L Y E E A L S K Y A F
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 97.5 87.7 N.A. 83.5 83.9 N.A. 72.5 59.1 N.A. 52.3 N.A. 42.8 44.5 N.A. 38.7
Protein Similarity: 100 99.6 98.6 93.1 N.A. 90.7 91.7 N.A. 84.4 72.5 N.A. 70.8 N.A. 60.9 64 N.A. 57.7
P-Site Identity: 100 100 100 93.3 N.A. 80 86.6 N.A. 86.6 86.6 N.A. 60 N.A. 13.3 46.6 N.A. 40
P-Site Similarity: 100 100 100 93.3 N.A. 100 100 N.A. 93.3 86.6 N.A. 80 N.A. 20 73.3 N.A. 73.3
Percent
Protein Identity: 35.2 32.5 N.A. 34.2 N.A. N.A.
Protein Similarity: 50.6 50.6 N.A. 55.1 N.A. N.A.
P-Site Identity: 40 6.6 N.A. 0 N.A. N.A.
P-Site Similarity: 40 26.6 N.A. 33.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 0 0 0 7 0 0 14 7 80 7 0 7 0 % A
% Cys: 0 0 7 0 0 0 0 0 0 0 7 0 0 0 0 % C
% Asp: 14 0 0 0 0 14 47 0 0 7 0 0 7 0 0 % D
% Glu: 47 7 0 0 7 7 34 7 7 80 0 60 7 0 0 % E
% Phe: 7 0 80 0 0 0 0 7 0 0 0 0 0 0 7 % F
% Gly: 0 0 0 14 0 67 0 0 7 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 7 0 0 0 7 0 0 0 % H
% Ile: 0 7 0 0 0 0 7 0 27 0 0 14 0 0 0 % I
% Lys: 0 0 0 74 40 0 0 0 7 0 0 7 0 0 0 % K
% Leu: 7 20 0 0 7 0 0 0 14 7 0 7 7 7 0 % L
% Met: 0 0 0 0 0 0 0 0 7 0 0 0 0 0 0 % M
% Asn: 7 0 7 0 7 0 0 0 0 0 0 0 0 7 0 % N
% Pro: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 54 0 0 7 0 7 0 0 0 0 0 0 7 0 % Q
% Arg: 7 7 0 0 20 0 0 7 0 0 7 0 0 0 7 % R
% Ser: 0 0 7 7 14 0 7 7 0 0 7 0 67 67 0 % S
% Thr: 0 0 0 0 0 0 0 0 7 0 0 0 0 0 0 % T
% Val: 7 7 0 0 0 0 0 0 14 0 0 0 7 7 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 7 0 67 0 0 0 0 7 0 87 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _