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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: COPS8 All Species: 33.64
Human Site: S183 Identified Species: 49.33
UniProt: Q99627 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q99627 NP_006701.1 209 23226 S183 F N K F I P L S E P A P V P P
Chimpanzee Pan troglodytes XP_001135161 209 23311 S183 F N K F I P L S E P A P L P P
Rhesus Macaque Macaca mulatta XP_001090380 647 71562 S621 F N K F I P L S E P A P V P P
Dog Lupus familis XP_534612 209 23195 S183 F N R F I P L S E P A P V P P
Cat Felis silvestris
Mouse Mus musculus Q8VBV7 209 23237 S183 L N R F I P L S E P A P V P P
Rat Rattus norvegicus Q6P4Z9 209 23217 S183 L N R F I P L S E P A P V P P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507694 204 22617 S178 F N R F I P L S E P A P V P P
Chicken Gallus gallus NP_001041472 207 22961 S181 F N R F I P S S E P A P V P P
Frog Xenopus laevis Q6GQA6 195 21737 S171 V M P K K P D S A P L S L I P
Zebra Danio Brachydanio rerio Q7ZUZ0 191 21527 P167 I M P Q K P D P P P V S L V P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q7KTH8 182 21413 A160 L K P K V Q E A P P A R G N D
Honey Bee Apis mellifera XP_391971 187 21201 S162 C K I Q K E E S N L V N E V C
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001203845 168 18975 R146 P K K P V P S R E A P A P S E
Poplar Tree Populus trichocarpa XP_002298193 199 22672 V176 L I V K K Q S V K T E Q K L D
Maize Zea mays NP_001141592 196 22092 S173 L T V K K P K S Q T N Q K L D
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P43255 197 22528 V174 A S V K K Q A V K R E Q K V D
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.7 31.6 98 N.A. 95.2 95.6 N.A. 84.2 88 74.1 67.9 N.A. 27.2 46.8 N.A. 43.5
Protein Similarity: 100 96.6 32.2 99.5 N.A. 98 98 N.A. 91.8 93.7 85.1 77.9 N.A. 46.8 63.1 N.A. 63.1
P-Site Identity: 100 93.3 100 93.3 N.A. 86.6 86.6 N.A. 93.3 86.6 26.6 20 N.A. 13.3 6.6 N.A. 20
P-Site Similarity: 100 100 100 100 N.A. 93.3 93.3 N.A. 100 93.3 33.3 26.6 N.A. 26.6 6.6 N.A. 26.6
Percent
Protein Identity: 32.5 32.5 N.A. 33.4 N.A. N.A.
Protein Similarity: 55.5 52.1 N.A. 53.1 N.A. N.A.
P-Site Identity: 0 13.3 N.A. 0 N.A. N.A.
P-Site Similarity: 6.6 20 N.A. 13.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 0 0 0 0 7 7 7 7 57 7 0 0 0 % A
% Cys: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % C
% Asp: 0 0 0 0 0 0 13 0 0 0 0 0 0 0 25 % D
% Glu: 0 0 0 0 0 7 13 0 57 0 13 0 7 0 7 % E
% Phe: 38 0 0 50 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 7 7 7 0 50 0 0 0 0 0 0 0 0 7 0 % I
% Lys: 0 19 25 32 38 0 7 0 13 0 0 0 19 0 0 % K
% Leu: 32 0 0 0 0 0 44 0 0 7 7 0 19 13 0 % L
% Met: 0 13 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 50 0 0 0 0 0 0 7 0 7 7 0 7 0 % N
% Pro: 7 0 19 7 0 75 0 7 13 69 7 50 7 50 63 % P
% Gln: 0 0 0 13 0 19 0 0 7 0 0 19 0 0 0 % Q
% Arg: 0 0 32 0 0 0 0 7 0 7 0 7 0 0 0 % R
% Ser: 0 7 0 0 0 0 19 69 0 0 0 13 0 7 0 % S
% Thr: 0 7 0 0 0 0 0 0 0 13 0 0 0 0 0 % T
% Val: 7 0 19 0 13 0 0 13 0 0 13 0 44 19 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _