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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: COPS8 All Species: 46.36
Human Site: T113 Identified Species: 68
UniProt: Q99627 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q99627 NP_006701.1 209 23226 T113 M E A L R D A T R R R A F A L
Chimpanzee Pan troglodytes XP_001135161 209 23311 T113 M E A L R D A T R R C A F A L
Rhesus Macaque Macaca mulatta XP_001090380 647 71562 T551 M E A L R D A T R R R A F A L
Dog Lupus familis XP_534612 209 23195 T113 M E A L R D A T R R R A F A L
Cat Felis silvestris
Mouse Mus musculus Q8VBV7 209 23237 T113 M E A L R D A T R R R A F A L
Rat Rattus norvegicus Q6P4Z9 209 23217 T113 M E A L R D A T R R R A F A L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507694 204 22617 T110 M E A L R D A T R R R A F G L
Chicken Gallus gallus NP_001041472 207 22961 T113 M E A I R D A T R R R A F G L
Frog Xenopus laevis Q6GQA6 195 21737 T115 M E A V R D A T Q Q R A F G L
Zebra Danio Brachydanio rerio Q7ZUZ0 191 21527 T111 M E A L R E S T R R R A Y G L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q7KTH8 182 21413 L106 L N K Q R E E L F K L M G S A
Honey Bee Apis mellifera XP_391971 187 21201 R106 A A L K D N V R E R A I T L I
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001203845 168 18975 L92 S D S I K Q R L F Q L V G N T
Poplar Tree Populus trichocarpa XP_002298193 199 22672 Y120 V A A F S E V Y T K R M F Q L
Maize Zea mays NP_001141592 196 22092 Y117 I T A F L E S Y R Q R I F K L
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P43255 197 22528 Y118 V A A F S D L Y T K R M F Q L
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.7 31.6 98 N.A. 95.2 95.6 N.A. 84.2 88 74.1 67.9 N.A. 27.2 46.8 N.A. 43.5
Protein Similarity: 100 96.6 32.2 99.5 N.A. 98 98 N.A. 91.8 93.7 85.1 77.9 N.A. 46.8 63.1 N.A. 63.1
P-Site Identity: 100 93.3 100 100 N.A. 100 100 N.A. 93.3 86.6 73.3 73.3 N.A. 6.6 6.6 N.A. 0
P-Site Similarity: 100 93.3 100 100 N.A. 100 100 N.A. 93.3 93.3 93.3 93.3 N.A. 33.3 20 N.A. 33.3
Percent
Protein Identity: 32.5 32.5 N.A. 33.4 N.A. N.A.
Protein Similarity: 55.5 52.1 N.A. 53.1 N.A. N.A.
P-Site Identity: 26.6 33.3 N.A. 33.3 N.A. N.A.
P-Site Similarity: 46.6 60 N.A. 46.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 19 82 0 0 0 57 0 0 0 7 63 0 38 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % C
% Asp: 0 7 0 0 7 63 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 63 0 0 0 25 7 0 7 0 0 0 0 0 0 % E
% Phe: 0 0 0 19 0 0 0 0 13 0 0 0 75 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 13 25 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 7 0 0 13 0 0 0 0 0 0 0 13 0 0 7 % I
% Lys: 0 0 7 7 7 0 0 0 0 19 0 0 0 7 0 % K
% Leu: 7 0 7 50 7 0 7 13 0 0 13 0 0 7 82 % L
% Met: 63 0 0 0 0 0 0 0 0 0 0 19 0 0 0 % M
% Asn: 0 7 0 0 0 7 0 0 0 0 0 0 0 7 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 7 0 7 0 0 7 19 0 0 0 13 0 % Q
% Arg: 0 0 0 0 69 0 7 7 63 63 75 0 0 0 0 % R
% Ser: 7 0 7 0 13 0 13 0 0 0 0 0 0 7 0 % S
% Thr: 0 7 0 0 0 0 0 63 13 0 0 0 7 0 7 % T
% Val: 13 0 0 7 0 0 13 0 0 0 0 7 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 19 0 0 0 0 7 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _