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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRPF18
All Species:
40.61
Human Site:
S228
Identified Species:
68.72
UniProt:
Q99633
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99633
NP_003666.1
342
39860
S228
A
T
Q
K
Q
T
E
S
Y
L
R
P
L
F
R
Chimpanzee
Pan troglodytes
XP_001142250
327
37980
S213
A
T
Q
K
Q
T
E
S
Y
L
R
P
L
F
R
Rhesus Macaque
Macaca mulatta
XP_001086532
351
40793
S237
A
T
Q
K
Q
T
E
S
Y
L
R
P
L
F
R
Dog
Lupus familis
XP_535182
342
39827
S228
A
T
Q
K
Q
T
E
S
Y
L
R
P
L
F
R
Cat
Felis silvestris
Mouse
Mus musculus
Q8BM39
342
39871
S228
A
T
Q
K
Q
T
E
S
Y
L
R
P
L
F
R
Rat
Rattus norvegicus
Q9JKB8
342
39847
S228
A
T
Q
K
Q
T
E
S
Y
L
R
P
L
F
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507839
342
39800
S228
A
T
Q
K
Q
T
E
S
Y
L
R
P
L
F
R
Chicken
Gallus gallus
XP_417229
342
39725
S228
A
T
Q
K
Q
T
E
S
Y
L
R
P
L
F
R
Frog
Xenopus laevis
Q5EAV6
342
39693
S228
A
T
Q
K
Q
T
E
S
Y
L
K
P
L
F
R
Zebra Danio
Brachydanio rerio
Q6GMH0
342
39523
S228
A
T
Q
K
Q
T
E
S
Y
L
E
P
L
F
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650776
340
39634
E222
V
I
Y
T
Q
T
K
E
Y
V
K
P
L
F
R
Honey Bee
Apis mellifera
XP_001121699
194
22227
A85
Q
L
N
S
R
S
T
A
E
K
M
S
T
R
G
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786157
346
39997
G229
A
T
Y
S
Q
T
E
G
Y
L
K
P
L
F
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P33411
251
28359
L143
F
L
D
T
K
K
A
L
F
P
L
L
L
Q
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.4
97.4
99.4
N.A.
99.1
98.8
N.A.
94.7
92.4
86.8
85
N.A.
50.5
34.5
N.A.
56.9
Protein Similarity:
100
94.4
97.4
100
N.A.
100
100
N.A.
98.2
96.4
92.6
92.6
N.A.
68.7
48.5
N.A.
75.1
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
100
100
93.3
93.3
N.A.
46.6
0
N.A.
66.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
100
93.3
N.A.
66.6
20
N.A.
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
24.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
44.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
79
0
0
0
0
0
8
8
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
79
8
8
0
8
0
0
0
0
% E
% Phe:
8
0
0
0
0
0
0
0
8
0
0
0
0
86
0
% F
% Gly:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
72
8
8
8
0
0
8
22
0
0
0
0
% K
% Leu:
0
15
0
0
0
0
0
8
0
79
8
8
93
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% M
% Asn:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
8
0
86
0
0
0
% P
% Gln:
8
0
72
0
86
0
0
0
0
0
0
0
0
8
0
% Q
% Arg:
0
0
0
0
8
0
0
0
0
0
58
0
0
8
79
% R
% Ser:
0
0
0
15
0
8
0
72
0
0
0
8
0
0
8
% S
% Thr:
0
79
0
15
0
86
8
0
0
0
0
0
8
0
0
% T
% Val:
8
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
15
0
0
0
0
0
86
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _