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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PRPF18 All Species: 39.7
Human Site: Y103 Identified Species: 67.18
UniProt: Q99633 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q99633 NP_003666.1 342 39860 Y103 R L F G E T D Y D A F Q R L R
Chimpanzee Pan troglodytes XP_001142250 327 37980 F91 G E T D Y D A F Q R L R K I E
Rhesus Macaque Macaca mulatta XP_001086532 351 40793 Y112 R L F G E T D Y D A F Q R L R
Dog Lupus familis XP_535182 342 39827 Y103 R L F G E T D Y D A F Q R L R
Cat Felis silvestris
Mouse Mus musculus Q8BM39 342 39871 Y103 R L F G E T D Y D A F Q R L R
Rat Rattus norvegicus Q9JKB8 342 39847 Y103 R L F G E T D Y D A F Q R L R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507839 342 39800 Y103 R L F G E T D Y D A F Q R L R
Chicken Gallus gallus XP_417229 342 39725 Y103 R L F G E T D Y D A F Q R L R
Frog Xenopus laevis Q5EAV6 342 39693 Y103 R L F G E T D Y E T F Q R L R
Zebra Danio Brachydanio rerio Q6GMH0 342 39523 Y103 R L F G E S D Y D A F Q R L R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_650776 340 39634 P98 L I F G E T E P E A F D R L R
Honey Bee Apis mellifera XP_001121699 194 22227
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_786157 346 39997 T104 R L F G E T D T E A F F R Q R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P33411 251 28359 C30 S K G V Q P P C T E K F Q P H
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.4 97.4 99.4 N.A. 99.1 98.8 N.A. 94.7 92.4 86.8 85 N.A. 50.5 34.5 N.A. 56.9
Protein Similarity: 100 94.4 97.4 100 N.A. 100 100 N.A. 98.2 96.4 92.6 92.6 N.A. 68.7 48.5 N.A. 75.1
P-Site Identity: 100 0 100 100 N.A. 100 100 N.A. 100 100 86.6 93.3 N.A. 60 0 N.A. 73.3
P-Site Similarity: 100 26.6 100 100 N.A. 100 100 N.A. 100 100 93.3 100 N.A. 80 0 N.A. 80
Percent
Protein Identity: N.A. N.A. N.A. N.A. 24.2 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 44.7 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 8 0 0 72 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 8 0 8 72 0 58 0 0 8 0 0 0 % D
% Glu: 0 8 0 0 79 0 8 0 22 8 0 0 0 0 8 % E
% Phe: 0 0 79 0 0 0 0 8 0 0 79 15 0 0 0 % F
% Gly: 8 0 8 79 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % H
% Ile: 0 8 0 0 0 0 0 0 0 0 0 0 0 8 0 % I
% Lys: 0 8 0 0 0 0 0 0 0 0 8 0 8 0 0 % K
% Leu: 8 72 0 0 0 0 0 0 0 0 8 0 0 72 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 8 8 8 0 0 0 0 0 8 0 % P
% Gln: 0 0 0 0 8 0 0 0 8 0 0 65 8 8 0 % Q
% Arg: 72 0 0 0 0 0 0 0 0 8 0 8 79 0 79 % R
% Ser: 8 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % S
% Thr: 0 0 8 0 0 72 0 8 8 8 0 0 0 0 0 % T
% Val: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 8 0 0 65 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _