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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRPF18
All Species:
53.94
Human Site:
Y269
Identified Species:
91.28
UniProt:
Q99633
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99633
NP_003666.1
342
39860
Y269
Y
V
K
A
N
D
A
Y
L
Q
M
A
I
G
N
Chimpanzee
Pan troglodytes
XP_001142250
327
37980
Y254
Y
V
K
A
N
D
A
Y
L
Q
M
A
I
G
N
Rhesus Macaque
Macaca mulatta
XP_001086532
351
40793
Y278
Y
V
K
A
N
D
A
Y
L
Q
M
A
I
G
N
Dog
Lupus familis
XP_535182
342
39827
Y269
Y
V
K
A
N
D
A
Y
L
Q
M
A
I
G
N
Cat
Felis silvestris
Mouse
Mus musculus
Q8BM39
342
39871
Y269
Y
V
K
A
N
D
A
Y
L
Q
M
A
I
G
N
Rat
Rattus norvegicus
Q9JKB8
342
39847
Y269
Y
V
K
A
N
D
A
Y
L
Q
M
A
I
G
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507839
342
39800
Y269
Y
V
K
A
N
D
A
Y
L
Q
M
A
I
G
N
Chicken
Gallus gallus
XP_417229
342
39725
Y269
Y
V
K
A
N
D
A
Y
L
Q
M
A
I
G
N
Frog
Xenopus laevis
Q5EAV6
342
39693
Y269
Y
V
K
A
N
D
A
Y
L
Q
M
A
I
G
N
Zebra Danio
Brachydanio rerio
Q6GMH0
342
39523
Y269
Y
V
K
A
N
D
A
Y
L
Q
M
A
I
G
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650776
340
39634
Y263
Y
I
T
A
S
D
A
Y
L
E
M
A
I
G
N
Honey Bee
Apis mellifera
XP_001121699
194
22227
Y121
Y
I
L
A
S
D
A
Y
L
Q
M
A
I
G
N
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786157
346
39997
Y270
Y
V
K
A
N
D
S
Y
L
Q
M
A
I
G
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P33411
251
28359
A179
Q
P
K
E
I
N
L
A
V
Q
S
Y
M
K
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.4
97.4
99.4
N.A.
99.1
98.8
N.A.
94.7
92.4
86.8
85
N.A.
50.5
34.5
N.A.
56.9
Protein Similarity:
100
94.4
97.4
100
N.A.
100
100
N.A.
98.2
96.4
92.6
92.6
N.A.
68.7
48.5
N.A.
75.1
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
73.3
80
N.A.
93.3
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
93.3
93.3
N.A.
100
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
24.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
44.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
93
0
0
86
8
0
0
0
93
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
93
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
8
0
0
0
0
0
8
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
93
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
15
0
0
8
0
0
0
0
0
0
0
93
0
0
% I
% Lys:
0
0
86
0
0
0
0
0
0
0
0
0
0
8
0
% K
% Leu:
0
0
8
0
0
0
8
0
93
0
0
0
0
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
93
0
8
0
0
% M
% Asn:
0
0
0
0
79
8
0
0
0
0
0
0
0
0
93
% N
% Pro:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
8
0
0
0
0
0
0
0
0
93
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
15
0
8
0
0
0
8
0
0
0
0
% S
% Thr:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
79
0
0
0
0
0
0
8
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
93
0
0
0
0
0
0
93
0
0
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _