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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SDHC All Species: 29.09
Human Site: T57 Identified Species: 58.18
UniProt: Q99643 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q99643 NP_001030588.1 169 18610 T57 R P L S P H I T I Y S W S L P
Chimpanzee Pan troglodytes XP_507919 132 14652 A27 P Q L C I R N A V P L G T T A
Rhesus Macaque Macaca mulatta XP_001118052 169 18608 T57 R P V S P H I T I Y S W S L P
Dog Lupus familis XP_536140 169 18495 T57 R P L S P H I T I Y S W S L P
Cat Felis silvestris
Mouse Mus musculus Q9CZB0 169 18363 T57 R P L S P H L T I Y K W S L P
Rat Rattus norvegicus NP_001005534 169 18184 T57 R P V S P H L T I Y R W S L P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518823 157 16301 G48 D R G L P A V G S P S G P V S
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001003523 144 16098 P39 T I Y K W S V P M A M S I S H
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_650047 171 18508 T59 R E L S P H L T I Y Q P Q L T
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P41956 182 19963 T59 R P I A P H L T V Y Q P Q L T
Sea Urchin Strong. purpuratus XP_001188484 116 13030 T10 P M M T S R V T M S M T A K Q
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P33421 198 22049 T82 R P I S P H L T I Y Q P Q L T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 71 98.8 91.7 N.A. 79.8 82.2 N.A. 55 N.A. N.A. 52.6 N.A. 38 N.A. 28.5 28.9
Protein Similarity: 100 74.5 99.4 96.4 N.A. 88.1 88.7 N.A. 65.6 N.A. N.A. 66.8 N.A. 56.1 N.A. 51 47.3
P-Site Identity: 100 6.6 93.3 100 N.A. 86.6 80 N.A. 13.3 N.A. N.A. 0 N.A. 60 N.A. 46.6 6.6
P-Site Similarity: 100 20 100 100 N.A. 93.3 93.3 N.A. 26.6 N.A. N.A. 13.3 N.A. 66.6 N.A. 73.3 40
Percent
Protein Identity: N.A. N.A. N.A. N.A. 25.7 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 40.9 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 60 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 73.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 9 0 9 0 9 0 9 0 0 9 0 9 % A
% Cys: 0 0 0 9 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 9 0 0 0 0 9 0 0 0 17 0 0 0 % G
% His: 0 0 0 0 0 67 0 0 0 0 0 0 0 0 9 % H
% Ile: 0 9 17 0 9 0 25 0 59 0 0 0 9 0 0 % I
% Lys: 0 0 0 9 0 0 0 0 0 0 9 0 0 9 0 % K
% Leu: 0 0 42 9 0 0 42 0 0 0 9 0 0 67 0 % L
% Met: 0 9 9 0 0 0 0 0 17 0 17 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 0 % N
% Pro: 17 59 0 0 75 0 0 9 0 17 0 25 9 0 42 % P
% Gln: 0 9 0 0 0 0 0 0 0 0 25 0 25 0 9 % Q
% Arg: 67 9 0 0 0 17 0 0 0 0 9 0 0 0 0 % R
% Ser: 0 0 0 59 9 9 0 0 9 9 34 9 42 9 9 % S
% Thr: 9 0 0 9 0 0 0 75 0 0 0 9 9 9 25 % T
% Val: 0 0 17 0 0 0 25 0 17 0 0 0 0 9 0 % V
% Trp: 0 0 0 0 9 0 0 0 0 0 0 42 0 0 0 % W
% Tyr: 0 0 9 0 0 0 0 0 0 67 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _