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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CHP All Species: 35.76
Human Site: S154 Identified Species: 49.17
UniProt: Q99653 Number Species: 16
    Phosphosite Substitution
    Charge Score: -0.06
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q99653 NP_009167.1 195 22456 S154 I S D E Q L G S I A D R T I Q
Chimpanzee Pan troglodytes XP_523319 364 40308 N323 V T E E Q L E N I A D R T V Q
Rhesus Macaque Macaca mulatta XP_001099860 154 17969 L115 L N S R S N K L H F A F R L Y
Dog Lupus familis XP_858323 176 20093 S135 I S D E Q L G S I A D R T I Q
Cat Felis silvestris
Mouse Mus musculus Q9D869 196 22518 S155 V T D E Q L E S I T D R T V Q
Rat Rattus norvegicus P61023 195 22414 S154 I S D E Q L G S I A D R T I Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520469 247 27862 S206 I S D E Q L G S I A D R T I Q
Chicken Gallus gallus Q5ZM44 195 22429 S154 I S D E Q L G S I A D R T I Q
Frog Xenopus laevis Q5U554 214 24808 S156 I E K E M A R S I A D G A M L
Zebra Danio Brachydanio rerio NP_956009 194 22400 S153 I S D E Q L G S I A D R T I Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24214 170 19248 Q131 L K D T Q L Q Q I V D K T I G
Honey Bee Apis mellifera XP_392514 189 21728 S148 I S E E Q L T S I A E R T I V
Nematode Worm Caenorhab. elegans P36608 191 22003 K147 E E E N T P E K R V D R I F R
Sea Urchin Strong. purpuratus XP_781855 190 22176 A149 I T E E Q L G A I A D R T L L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9C5P6 226 26010 S160 L S D H V I E S I I D K T F E
Baker's Yeast Sacchar. cerevisiae P25296 175 19620 Q134 L D D E Q L Q Q I V D R T I V
Red Bread Mold Neurospora crassa P87072 174 19751 Q134 L K D Q Q L Q Q I V D K T I M
Conservation
Percent
Protein Identity: 100 34.8 78.9 89.7 N.A. 59.6 98.9 N.A. 78.5 96.9 32.2 89.2 N.A. 38.9 67.6 27.1 63
Protein Similarity: 100 44.2 78.9 90.2 N.A. 77.5 99.4 N.A. 78.9 97.9 49 94.8 N.A. 56.4 80 50.2 74.8
P-Site Identity: 100 60 0 100 N.A. 66.6 100 N.A. 100 100 40 100 N.A. 46.6 73.3 13.3 66.6
P-Site Similarity: 100 93.3 20 100 N.A. 86.6 100 N.A. 100 100 46.6 100 N.A. 60 86.6 26.6 93.3
Percent
Protein Identity: N.A. N.A. N.A. 22.1 37.4 39.4
Protein Similarity: N.A. N.A. N.A. 39.8 55.9 57.9
P-Site Identity: N.A. N.A. N.A. 40 60 46.6
P-Site Similarity: N.A. N.A. N.A. 66.6 66.6 66.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 6 0 6 0 59 6 0 6 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 6 65 0 0 0 0 0 0 0 89 0 0 0 0 % D
% Glu: 6 12 24 71 0 0 24 0 0 0 6 0 0 0 6 % E
% Phe: 0 0 0 0 0 0 0 0 0 6 0 6 0 12 0 % F
% Gly: 0 0 0 0 0 0 42 0 0 0 0 6 0 0 6 % G
% His: 0 0 0 6 0 0 0 0 6 0 0 0 0 0 0 % H
% Ile: 53 0 0 0 0 6 0 0 89 6 0 0 6 59 0 % I
% Lys: 0 12 6 0 0 0 6 6 0 0 0 18 0 0 0 % K
% Leu: 30 0 0 0 0 77 0 6 0 0 0 0 0 12 12 % L
% Met: 0 0 0 0 6 0 0 0 0 0 0 0 0 6 6 % M
% Asn: 0 6 0 6 0 6 0 6 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 6 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 6 77 0 18 18 0 0 0 0 0 0 48 % Q
% Arg: 0 0 0 6 0 0 6 0 6 0 0 71 6 0 6 % R
% Ser: 0 48 6 0 6 0 0 59 0 0 0 0 0 0 0 % S
% Thr: 0 18 0 6 6 0 6 0 0 6 0 0 83 0 0 % T
% Val: 12 0 0 0 6 0 0 0 0 24 0 0 0 12 12 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _