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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CHP All Species: 13.64
Human Site: S169 Identified Species: 18.75
UniProt: Q99653 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q99653 NP_009167.1 195 22456 S169 E A D Q D G D S A I S F T E F
Chimpanzee Pan troglodytes XP_523319 364 40308 G338 E A D E D G D G A V S F V E F
Rhesus Macaque Macaca mulatta XP_001099860 154 17969 I130 D L D K D E K I S R D E L L Q
Dog Lupus familis XP_858323 176 20093 S150 E A D Q D G D S A I S F T E F
Cat Felis silvestris
Mouse Mus musculus Q9D869 196 22518 G170 E A D E D G D G A V S F L E F
Rat Rattus norvegicus P61023 195 22414 S169 E A D Q D G D S A I S F T E F
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520469 247 27862 S221 E A D Q D G D S A I S F T E F
Chicken Gallus gallus Q5ZM44 195 22429 C169 E A D Q D G D C A I S F A E F
Frog Xenopus laevis Q5U554 214 24808 G171 E A A S I C V G Q M E P D Q V
Zebra Danio Brachydanio rerio NP_956009 194 22400 M168 E A D T N G D M C I S F N E F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24214 170 19248 G146 F A D K D E D G K I S F D E F
Honey Bee Apis mellifera XP_392514 189 21728 G163 E A D E N G D G M I S F E E F
Nematode Worm Caenorhab. elegans P36608 191 22003 A162 M M D K N N D A Q L T L E E F
Sea Urchin Strong. purpuratus XP_781855 190 22176 G164 E A D L D E D G Q I S F E E F
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9C5P6 226 26010 G175 E A D T K L D G K I D K E E W
Baker's Yeast Sacchar. cerevisiae P25296 175 19620 G149 E N D S D G D G R L S F E E F
Red Bread Mold Neurospora crassa P87072 174 19751 G149 E A D L D K D G K I S F E E F
Conservation
Percent
Protein Identity: 100 34.8 78.9 89.7 N.A. 59.6 98.9 N.A. 78.5 96.9 32.2 89.2 N.A. 38.9 67.6 27.1 63
Protein Similarity: 100 44.2 78.9 90.2 N.A. 77.5 99.4 N.A. 78.9 97.9 49 94.8 N.A. 56.4 80 50.2 74.8
P-Site Identity: 100 73.3 13.3 100 N.A. 73.3 100 N.A. 100 86.6 13.3 66.6 N.A. 60 66.6 26.6 66.6
P-Site Similarity: 100 86.6 33.3 100 N.A. 86.6 100 N.A. 100 86.6 26.6 73.3 N.A. 66.6 80 60 66.6
Percent
Protein Identity: N.A. N.A. N.A. 22.1 37.4 39.4
Protein Similarity: N.A. N.A. N.A. 39.8 55.9 57.9
P-Site Identity: N.A. N.A. N.A. 40 60 66.6
P-Site Similarity: N.A. N.A. N.A. 46.6 66.6 66.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 83 6 0 0 0 0 6 42 0 0 0 6 0 0 % A
% Cys: 0 0 0 0 0 6 0 6 6 0 0 0 0 0 0 % C
% Asp: 6 0 95 0 71 0 89 0 0 0 12 0 12 0 0 % D
% Glu: 83 0 0 18 0 18 0 0 0 0 6 6 36 89 0 % E
% Phe: 6 0 0 0 0 0 0 0 0 0 0 77 0 0 83 % F
% Gly: 0 0 0 0 0 59 0 53 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 6 0 0 6 0 65 0 0 0 0 0 % I
% Lys: 0 0 0 18 6 6 6 0 18 0 0 6 0 0 0 % K
% Leu: 0 6 0 12 0 6 0 0 0 12 0 6 12 6 0 % L
% Met: 6 6 0 0 0 0 0 6 6 6 0 0 0 0 0 % M
% Asn: 0 6 0 0 18 6 0 0 0 0 0 0 6 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 6 0 0 0 % P
% Gln: 0 0 0 30 0 0 0 0 18 0 0 0 0 6 6 % Q
% Arg: 0 0 0 0 0 0 0 0 6 6 0 0 0 0 0 % R
% Ser: 0 0 0 12 0 0 0 24 6 0 77 0 0 0 0 % S
% Thr: 0 0 0 12 0 0 0 0 0 0 6 0 24 0 0 % T
% Val: 0 0 0 0 0 0 6 0 0 12 0 0 6 0 6 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _