Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CHP All Species: 43.64
Human Site: S172 Identified Species: 60
UniProt: Q99653 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0.19
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q99653 NP_009167.1 195 22456 S172 Q D G D S A I S F T E F V K V
Chimpanzee Pan troglodytes XP_523319 364 40308 S341 E D G D G A V S F V E F T K S
Rhesus Macaque Macaca mulatta XP_001099860 154 17969 D133 K D E K I S R D E L L Q V L E
Dog Lupus familis XP_858323 176 20093 S153 Q D G D S A I S F T E F V K V
Cat Felis silvestris
Mouse Mus musculus Q9D869 196 22518 S173 E D G D G A V S F L E F T K S
Rat Rattus norvegicus P61023 195 22414 S172 Q D G D S A I S F T E F V K V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520469 247 27862 S224 Q D G D S A I S F T E F V K V
Chicken Gallus gallus Q5ZM44 195 22429 S172 Q D G D C A I S F A E F V K V
Frog Xenopus laevis Q5U554 214 24808 E174 S I C V G Q M E P D Q V Y E G
Zebra Danio Brachydanio rerio NP_956009 194 22400 S171 T N G D M C I S F N E F T K V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24214 170 19248 S149 K D E D G K I S F D E F C S V
Honey Bee Apis mellifera XP_392514 189 21728 S166 E N G D G M I S F E E F C K A
Nematode Worm Caenorhab. elegans P36608 191 22003 T165 K N N D A Q L T L E E F K E G
Sea Urchin Strong. purpuratus XP_781855 190 22176 S167 L D E D G Q I S F E E F I K A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9C5P6 226 26010 D178 T K L D G K I D K E E W R S L
Baker's Yeast Sacchar. cerevisiae P25296 175 19620 S152 S D G D G R L S F E E F K N A
Red Bread Mold Neurospora crassa P87072 174 19751 S152 L D K D G K I S F E E F T K M
Conservation
Percent
Protein Identity: 100 34.8 78.9 89.7 N.A. 59.6 98.9 N.A. 78.5 96.9 32.2 89.2 N.A. 38.9 67.6 27.1 63
Protein Similarity: 100 44.2 78.9 90.2 N.A. 77.5 99.4 N.A. 78.9 97.9 49 94.8 N.A. 56.4 80 50.2 74.8
P-Site Identity: 100 60 13.3 100 N.A. 60 100 N.A. 100 86.6 0 60 N.A. 53.3 53.3 20 53.3
P-Site Similarity: 100 73.3 26.6 100 N.A. 73.3 100 N.A. 100 86.6 20 66.6 N.A. 60 66.6 60 60
Percent
Protein Identity: N.A. N.A. N.A. 22.1 37.4 39.4
Protein Similarity: N.A. N.A. N.A. 39.8 55.9 57.9
P-Site Identity: N.A. N.A. N.A. 20 46.6 53.3
P-Site Similarity: N.A. N.A. N.A. 33.3 53.3 60
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 6 42 0 0 0 6 0 0 0 0 18 % A
% Cys: 0 0 6 0 6 6 0 0 0 0 0 0 12 0 0 % C
% Asp: 0 71 0 89 0 0 0 12 0 12 0 0 0 0 0 % D
% Glu: 18 0 18 0 0 0 0 6 6 36 89 0 0 12 6 % E
% Phe: 0 0 0 0 0 0 0 0 77 0 0 83 0 0 0 % F
% Gly: 0 0 59 0 53 0 0 0 0 0 0 0 0 0 12 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 6 0 0 6 0 65 0 0 0 0 0 6 0 0 % I
% Lys: 18 6 6 6 0 18 0 0 6 0 0 0 12 65 0 % K
% Leu: 12 0 6 0 0 0 12 0 6 12 6 0 0 6 6 % L
% Met: 0 0 0 0 6 6 6 0 0 0 0 0 0 0 6 % M
% Asn: 0 18 6 0 0 0 0 0 0 6 0 0 0 6 0 % N
% Pro: 0 0 0 0 0 0 0 0 6 0 0 0 0 0 0 % P
% Gln: 30 0 0 0 0 18 0 0 0 0 6 6 0 0 0 % Q
% Arg: 0 0 0 0 0 6 6 0 0 0 0 0 6 0 0 % R
% Ser: 12 0 0 0 24 6 0 77 0 0 0 0 0 12 12 % S
% Thr: 12 0 0 0 0 0 0 6 0 24 0 0 24 0 0 % T
% Val: 0 0 0 6 0 0 12 0 0 6 0 6 36 0 42 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 6 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 6 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _