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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CHP All Species: 22.12
Human Site: S26 Identified Species: 30.42
UniProt: Q99653 Number Species: 16
    Phosphosite Substitution
    Charge Score: -0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q99653 NP_009167.1 195 22456 S26 K E T G F S H S Q I T R L Y S
Chimpanzee Pan troglodytes XP_523319 364 40308 A194 R E T G F S Q A S L L R L H H
Rhesus Macaque Macaca mulatta XP_001099860 154 17969 E13 S T L L R D E E L E E I K K E
Dog Lupus familis XP_858323 176 20093 S26 K E T G F S H S Q I T R L Y S
Cat Felis silvestris
Mouse Mus musculus Q9D869 196 22518 A26 R E T G F S Q A S L L R L Y H
Rat Rattus norvegicus P61023 195 22414 S26 K E T G F S H S Q I T R L Y S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520469 247 27862 S78 N T F S V S H S Q I T R L Y S
Chicken Gallus gallus Q5ZM44 195 22429 S26 K E T G F S H S Q I T R L Y S
Frog Xenopus laevis Q5U554 214 24808 E26 G F S A E Q I E H L H K R F K
Zebra Danio Brachydanio rerio NP_956009 194 22400 S26 K E T G F S H S Q I T R L Y S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24214 170 19248 R26 E I R R L G K R F R K L D L D
Honey Bee Apis mellifera XP_392514 189 21728 N26 E A T G F T P N Q I E R L Y S
Nematode Worm Caenorhab. elegans P36608 191 22003 Y31 E K E I K Q W Y K G F V R D C
Sea Urchin Strong. purpuratus XP_781855 190 22176 K26 Q E T G F S P K Q I V R L Y S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9C5P6 226 26010 N43 R G T V F T V N E I E A L Y E
Baker's Yeast Sacchar. cerevisiae P25296 175 19620 R29 E I E R L R K R F M K L D R D
Red Bread Mold Neurospora crassa P87072 174 19751 R29 E V D R L R K R F M K L D K D
Conservation
Percent
Protein Identity: 100 34.8 78.9 89.7 N.A. 59.6 98.9 N.A. 78.5 96.9 32.2 89.2 N.A. 38.9 67.6 27.1 63
Protein Similarity: 100 44.2 78.9 90.2 N.A. 77.5 99.4 N.A. 78.9 97.9 49 94.8 N.A. 56.4 80 50.2 74.8
P-Site Identity: 100 46.6 0 100 N.A. 53.3 100 N.A. 66.6 100 0 100 N.A. 0 60 0 73.3
P-Site Similarity: 100 73.3 0 100 N.A. 73.3 100 N.A. 66.6 100 26.6 100 N.A. 6.6 80 20 80
Percent
Protein Identity: N.A. N.A. N.A. 22.1 37.4 39.4
Protein Similarity: N.A. N.A. N.A. 39.8 55.9 57.9
P-Site Identity: N.A. N.A. N.A. 33.3 0 0
P-Site Similarity: N.A. N.A. N.A. 60 13.3 13.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 6 0 6 0 0 0 12 0 0 0 6 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 % C
% Asp: 0 0 6 0 0 6 0 0 0 0 0 0 18 6 18 % D
% Glu: 30 48 12 0 6 0 6 12 6 6 18 0 0 0 12 % E
% Phe: 0 6 6 0 59 0 0 0 18 0 6 0 0 6 0 % F
% Gly: 6 6 0 53 0 6 0 0 0 6 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 36 0 6 0 6 0 0 6 12 % H
% Ile: 0 12 0 6 0 0 6 0 0 53 0 6 0 0 0 % I
% Lys: 30 6 0 0 6 0 18 6 6 0 18 6 6 12 6 % K
% Leu: 0 0 6 6 18 0 0 0 6 18 12 18 65 6 0 % L
% Met: 0 0 0 0 0 0 0 0 0 12 0 0 0 0 0 % M
% Asn: 6 0 0 0 0 0 0 12 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 12 0 0 0 0 0 0 0 0 % P
% Gln: 6 0 0 0 0 12 12 0 48 0 0 0 0 0 0 % Q
% Arg: 18 0 6 18 6 12 0 18 0 6 0 59 12 6 0 % R
% Ser: 6 0 6 6 0 53 0 36 12 0 0 0 0 0 48 % S
% Thr: 0 12 59 0 0 12 0 0 0 0 36 0 0 0 0 % T
% Val: 0 6 0 6 6 0 6 0 0 0 6 6 0 0 0 % V
% Trp: 0 0 0 0 0 0 6 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 6 0 0 0 0 0 59 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _