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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CHP All Species: 34.24
Human Site: S47 Identified Species: 47.08
UniProt: Q99653 Number Species: 16
    Phosphosite Substitution
    Charge Score: -0.06
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q99653 NP_009167.1 195 22456 S47 K G E N G T L S R E D F Q R I
Chimpanzee Pan troglodytes XP_523319 364 40308 S215 R N K K G Y L S R M D L Q Q I
Rhesus Macaque Macaca mulatta XP_001099860 154 17969 R34 Q I T R L Y S R F T S L D K G
Dog Lupus familis XP_858323 176 20093 S47 K G E N G T L S R E D F Q R I
Cat Felis silvestris
Mouse Mus musculus Q9D869 196 22518 S47 R D E K G F L S R L D L Q Q I
Rat Rattus norvegicus P61023 195 22414 S47 K G E N G T L S R E D F Q R I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520469 247 27862 S99 K G E N G T L S R E D F Q R I
Chicken Gallus gallus Q5ZM44 195 22429 S47 K G E N G T L S R E D F Q R I
Frog Xenopus laevis Q5U554 214 24808 L47 P T I R R G H L N D I S D L V
Zebra Danio Brachydanio rerio NP_956009 194 22400 S47 K G E N G G L S R E D F Q R I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24214 170 19248 P47 V D E F M S L P E L Q Q N P L
Honey Bee Apis mellifera XP_392514 189 21728 S47 R G D C G T L S R E D F L R I
Nematode Worm Caenorhab. elegans P36608 191 22003 Y52 E A G F Q K I Y K Q F F P Q G
Sea Urchin Strong. purpuratus XP_781855 190 22176 R47 K S D R G M L R V E D L Y R I
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9C5P6 226 26010 E64 K N G L I D K E Q F Q L V L F
Baker's Yeast Sacchar. cerevisiae P25296 175 19620 P50 K N E F M S I P G V S S N P L
Red Bread Mold Neurospora crassa P87072 174 19751 P50 R E E F L S L P Q I S T N P L
Conservation
Percent
Protein Identity: 100 34.8 78.9 89.7 N.A. 59.6 98.9 N.A. 78.5 96.9 32.2 89.2 N.A. 38.9 67.6 27.1 63
Protein Similarity: 100 44.2 78.9 90.2 N.A. 77.5 99.4 N.A. 78.9 97.9 49 94.8 N.A. 56.4 80 50.2 74.8
P-Site Identity: 100 46.6 0 100 N.A. 53.3 100 N.A. 100 100 0 93.3 N.A. 13.3 73.3 6.6 46.6
P-Site Similarity: 100 66.6 13.3 100 N.A. 66.6 100 N.A. 100 100 13.3 93.3 N.A. 26.6 86.6 40 53.3
Percent
Protein Identity: N.A. N.A. N.A. 22.1 37.4 39.4
Protein Similarity: N.A. N.A. N.A. 39.8 55.9 57.9
P-Site Identity: N.A. N.A. N.A. 6.6 13.3 13.3
P-Site Similarity: N.A. N.A. N.A. 13.3 33.3 40
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 6 0 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 6 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 12 12 0 0 6 0 0 0 6 59 0 12 0 0 % D
% Glu: 6 6 59 0 0 0 0 6 6 48 0 0 0 0 0 % E
% Phe: 0 0 0 24 0 6 0 0 6 6 6 48 0 0 6 % F
% Gly: 0 42 12 0 59 12 0 0 6 0 0 0 0 0 12 % G
% His: 0 0 0 0 0 0 6 0 0 0 0 0 0 0 0 % H
% Ile: 0 6 6 0 6 0 12 0 0 6 6 0 0 0 59 % I
% Lys: 53 0 6 12 0 6 6 0 6 0 0 0 0 6 0 % K
% Leu: 0 0 0 6 12 0 71 6 0 12 0 30 6 12 18 % L
% Met: 0 0 0 0 12 6 0 0 0 6 0 0 0 0 0 % M
% Asn: 0 18 0 36 0 0 0 0 6 0 0 0 18 0 0 % N
% Pro: 6 0 0 0 0 0 0 18 0 0 0 0 6 18 0 % P
% Gln: 6 0 0 0 6 0 0 0 12 6 12 6 48 18 0 % Q
% Arg: 24 0 0 18 6 0 0 12 53 0 0 0 0 48 0 % R
% Ser: 0 6 0 0 0 18 6 53 0 0 18 12 0 0 0 % S
% Thr: 0 6 6 0 0 36 0 0 0 6 0 6 0 0 0 % T
% Val: 6 0 0 0 0 0 0 0 6 6 0 0 6 0 6 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 12 0 6 0 0 0 0 6 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _