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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CHP All Species: 36.46
Human Site: S6 Identified Species: 50.13
UniProt: Q99653 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q99653 NP_009167.1 195 22456 S6 _ _ M G S R A S T L L R D E E
Chimpanzee Pan troglodytes XP_523319 364 40308 S174 S A M G S R S S H A A V I P D
Rhesus Macaque Macaca mulatta XP_001099860 154 17969
Dog Lupus familis XP_858323 176 20093 S6 _ _ M G S R A S T L L R D E E
Cat Felis silvestris
Mouse Mus musculus Q9D869 196 22518 S6 _ _ M G S R S S H I A L I P D
Rat Rattus norvegicus P61023 195 22414 S6 _ _ M G S R A S T L L R D E E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520469 247 27862 E58 S A P H P V S E Q C S A P S K
Chicken Gallus gallus Q5ZM44 195 22429 S6 _ _ M G S R A S T L L R D E E
Frog Xenopus laevis Q5U554 214 24808 S6 _ _ M G L S H S H S V E T R E
Zebra Danio Brachydanio rerio NP_956009 194 22400 S6 _ _ M G S R A S S L L R E E D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24214 170 19248 S6 _ _ M G N E T S L P M E M C S
Honey Bee Apis mellifera XP_392514 189 21728 S6 _ _ M G N R S S L L L R E E E
Nematode Worm Caenorhab. elegans P36608 191 22003 S11 G N S K L K S S Q I R D L A E
Sea Urchin Strong. purpuratus XP_781855 190 22176 S6 _ _ M G S R T S S L L Q Q E E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9C5P6 226 26010 D23 L L T C C D A D P P K V R Q N
Baker's Yeast Sacchar. cerevisiae P25296 175 19620 V9 G A A P S K I V D G L L E D T
Red Bread Mold Neurospora crassa P87072 174 19751 L9 G N T T S S V L D N I V Q G S
Conservation
Percent
Protein Identity: 100 34.8 78.9 89.7 N.A. 59.6 98.9 N.A. 78.5 96.9 32.2 89.2 N.A. 38.9 67.6 27.1 63
Protein Similarity: 100 44.2 78.9 90.2 N.A. 77.5 99.4 N.A. 78.9 97.9 49 94.8 N.A. 56.4 80 50.2 74.8
P-Site Identity: 100 33.3 0 100 N.A. 38.4 100 N.A. 0 100 30.7 76.9 N.A. 23 69.2 13.3 69.2
P-Site Similarity: 100 46.6 0 100 N.A. 61.5 100 N.A. 13.3 100 38.4 100 N.A. 38.4 92.3 40 84.6
Percent
Protein Identity: N.A. N.A. N.A. 22.1 37.4 39.4
Protein Similarity: N.A. N.A. N.A. 39.8 55.9 57.9
P-Site Identity: N.A. N.A. N.A. 6.6 13.3 6.6
P-Site Similarity: N.A. N.A. N.A. 13.3 40 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 18 6 0 0 0 36 0 0 6 12 6 0 6 0 % A
% Cys: 0 0 0 6 6 0 0 0 0 6 0 0 0 6 0 % C
% Asp: 0 0 0 0 0 6 0 6 12 0 0 6 24 6 18 % D
% Glu: 0 0 0 0 0 6 0 6 0 0 0 12 18 42 48 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 18 0 0 65 0 0 0 0 0 6 0 0 0 6 0 % G
% His: 0 0 0 6 0 0 6 0 18 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 6 0 0 12 6 0 12 0 0 % I
% Lys: 0 0 0 6 0 12 0 0 0 0 6 0 0 0 6 % K
% Leu: 6 6 0 0 12 0 0 6 12 42 48 12 6 0 0 % L
% Met: 0 0 65 0 0 0 0 0 0 0 6 0 6 0 0 % M
% Asn: 0 12 0 0 12 0 0 0 0 6 0 0 0 0 6 % N
% Pro: 0 0 6 6 6 0 0 0 6 12 0 0 6 12 0 % P
% Gln: 0 0 0 0 0 0 0 0 12 0 0 6 12 6 0 % Q
% Arg: 0 0 0 0 0 53 0 0 0 0 6 36 6 6 0 % R
% Ser: 12 0 6 0 59 12 30 71 12 6 6 0 0 6 12 % S
% Thr: 0 0 12 6 0 0 12 0 24 0 0 0 6 0 6 % T
% Val: 0 0 0 0 0 6 6 6 0 0 6 18 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 59 59 0 0 0 0 0 0 0 0 0 0 0 0 0 % _