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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CHP All Species: 50.3
Human Site: T159 Identified Species: 69.17
UniProt: Q99653 Number Species: 16
    Phosphosite Substitution
    Charge Score: -0.06
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q99653 NP_009167.1 195 22456 T159 L G S I A D R T I Q E A D Q D
Chimpanzee Pan troglodytes XP_523319 364 40308 T328 L E N I A D R T V Q E A D E D
Rhesus Macaque Macaca mulatta XP_001099860 154 17969 R120 N K L H F A F R L Y D L D K D
Dog Lupus familis XP_858323 176 20093 T140 L G S I A D R T I Q E A D Q D
Cat Felis silvestris
Mouse Mus musculus Q9D869 196 22518 T160 L E S I T D R T V Q E A D E D
Rat Rattus norvegicus P61023 195 22414 T159 L G S I A D R T I Q E A D Q D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520469 247 27862 T211 L G S I A D R T I Q E A D Q D
Chicken Gallus gallus Q5ZM44 195 22429 T159 L G S I A D R T I Q E A D Q D
Frog Xenopus laevis Q5U554 214 24808 A161 A R S I A D G A M L E A A S I
Zebra Danio Brachydanio rerio NP_956009 194 22400 T158 L G S I A D R T I Q E A D T N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24214 170 19248 T136 L Q Q I V D K T I G F A D K D
Honey Bee Apis mellifera XP_392514 189 21728 T153 L T S I A E R T I V E A D E N
Nematode Worm Caenorhab. elegans P36608 191 22003 I152 P E K R V D R I F R M M D K N
Sea Urchin Strong. purpuratus XP_781855 190 22176 T154 L G A I A D R T L L E A D L D
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9C5P6 226 26010 T165 I E S I I D K T F E E A D T K
Baker's Yeast Sacchar. cerevisiae P25296 175 19620 T139 L Q Q I V D R T I V E N D S D
Red Bread Mold Neurospora crassa P87072 174 19751 T139 L Q Q I V D K T I M E A D L D
Conservation
Percent
Protein Identity: 100 34.8 78.9 89.7 N.A. 59.6 98.9 N.A. 78.5 96.9 32.2 89.2 N.A. 38.9 67.6 27.1 63
Protein Similarity: 100 44.2 78.9 90.2 N.A. 77.5 99.4 N.A. 78.9 97.9 49 94.8 N.A. 56.4 80 50.2 74.8
P-Site Identity: 100 73.3 13.3 100 N.A. 73.3 100 N.A. 100 100 40 86.6 N.A. 53.3 66.6 20 73.3
P-Site Similarity: 100 93.3 33.3 100 N.A. 86.6 100 N.A. 100 100 46.6 93.3 N.A. 66.6 86.6 40 86.6
Percent
Protein Identity: N.A. N.A. N.A. 22.1 37.4 39.4
Protein Similarity: N.A. N.A. N.A. 39.8 55.9 57.9
P-Site Identity: N.A. N.A. N.A. 46.6 60 60
P-Site Similarity: N.A. N.A. N.A. 66.6 60 66.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 6 0 6 0 59 6 0 6 0 0 0 83 6 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 89 0 0 0 0 6 0 95 0 71 % D
% Glu: 0 24 0 0 0 6 0 0 0 6 83 0 0 18 0 % E
% Phe: 0 0 0 0 6 0 6 0 12 0 6 0 0 0 0 % F
% Gly: 0 42 0 0 0 0 6 0 0 6 0 0 0 0 0 % G
% His: 0 0 0 6 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 6 0 0 89 6 0 0 6 59 0 0 0 0 0 6 % I
% Lys: 0 6 6 0 0 0 18 0 0 0 0 0 0 18 6 % K
% Leu: 77 0 6 0 0 0 0 0 12 12 0 6 0 12 0 % L
% Met: 0 0 0 0 0 0 0 0 6 6 6 6 0 0 0 % M
% Asn: 6 0 6 0 0 0 0 0 0 0 0 6 0 0 18 % N
% Pro: 6 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 18 18 0 0 0 0 0 0 48 0 0 0 30 0 % Q
% Arg: 0 6 0 6 0 0 71 6 0 6 0 0 0 0 0 % R
% Ser: 0 0 59 0 0 0 0 0 0 0 0 0 0 12 0 % S
% Thr: 0 6 0 0 6 0 0 83 0 0 0 0 0 12 0 % T
% Val: 0 0 0 0 24 0 0 0 12 12 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 6 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _