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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP3K5
All Species:
26.67
Human Site:
Y475
Identified Species:
58.67
UniProt:
Q99683
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99683
NP_005914.1
1374
154537
Y475
N
L
E
K
L
Q
S
Y
W
E
V
G
F
F
L
Chimpanzee
Pan troglodytes
XP_001171211
1375
154924
Y476
N
L
E
K
L
Q
S
Y
W
E
V
G
F
F
L
Rhesus Macaque
Macaca mulatta
XP_001111127
1297
143635
Y438
C
V
E
K
M
Q
Y
Y
W
D
V
G
F
Y
L
Dog
Lupus familis
XP_533420
1645
181128
Y746
N
L
E
K
L
Q
S
Y
W
E
V
G
F
F
L
Cat
Felis silvestris
Mouse
Mus musculus
O35099
1380
154441
Y482
N
L
E
K
L
Q
S
Y
W
E
V
G
F
F
L
Rat
Rattus norvegicus
XP_001073260
1338
150427
Y446
N
L
E
K
L
Q
S
Y
W
E
V
G
F
F
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511920
1243
141469
V425
A
T
K
A
D
V
T
V
V
R
F
P
V
L
I
Chicken
Gallus gallus
XP_419725
1260
143069
V425
H
T
A
K
Q
E
L
V
D
F
W
M
D
F
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001155222
1364
153160
Y462
S
L
D
R
L
Q
S
Y
W
D
V
G
F
F
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477089
1363
155478
K426
L
I
H
R
F
R
K
K
P
E
E
R
Q
P
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001202919
1288
145042
V428
N
I
Q
M
I
C
R
V
R
P
T
S
D
E
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
44.9
68
N.A.
94.1
92.7
N.A.
84.4
80.4
N.A.
71.7
N.A.
40.6
N.A.
N.A.
44.6
Protein Similarity:
100
99.4
61.3
73.1
N.A.
95.8
94.4
N.A.
87.8
87
N.A.
84.1
N.A.
58.2
N.A.
N.A.
60.7
P-Site Identity:
100
100
60
100
N.A.
100
100
N.A.
0
20
N.A.
73.3
N.A.
6.6
N.A.
N.A.
6.6
P-Site Similarity:
100
100
86.6
100
N.A.
100
100
N.A.
20
33.3
N.A.
100
N.A.
26.6
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
10
10
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
10
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
10
0
10
0
0
0
10
19
0
0
19
0
0
% D
% Glu:
0
0
55
0
0
10
0
0
0
55
10
0
0
10
10
% E
% Phe:
0
0
0
0
10
0
0
0
0
10
10
0
64
64
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
64
0
0
0
% G
% His:
10
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
19
0
0
10
0
0
0
0
0
0
0
0
0
10
% I
% Lys:
0
0
10
64
0
0
10
10
0
0
0
0
0
0
0
% K
% Leu:
10
55
0
0
55
0
10
0
0
0
0
0
0
10
73
% L
% Met:
0
0
0
10
10
0
0
0
0
0
0
10
0
0
0
% M
% Asn:
55
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
10
10
0
10
0
10
10
% P
% Gln:
0
0
10
0
10
64
0
0
0
0
0
0
10
0
0
% Q
% Arg:
0
0
0
19
0
10
10
0
10
10
0
10
0
0
0
% R
% Ser:
10
0
0
0
0
0
55
0
0
0
0
10
0
0
0
% S
% Thr:
0
19
0
0
0
0
10
0
0
0
10
0
0
0
0
% T
% Val:
0
10
0
0
0
10
0
28
10
0
64
0
10
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
64
0
10
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
10
64
0
0
0
0
0
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _