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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MGLL All Species: 24.55
Human Site: Y248 Identified Species: 49.09
UniProt: Q99685 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q99685 NP_001003794.1 303 33261 Y248 L C D S K G A Y L L M E L A K
Chimpanzee Pan troglodytes XP_001140395 142 15737 L88 C D S K G A Y L L M E L A K S
Rhesus Macaque Macaca mulatta XP_001099193 305 33406 Y250 L C D S K G A Y L L M E S A K
Dog Lupus familis XP_856683 304 33364 Y248 L C D S K G A Y L L M E S A K
Cat Felis silvestris
Mouse Mus musculus O35678 303 33369 Y248 L C D S K G A Y L L M E S S R
Rat Rattus norvegicus Q8R431 303 33481 Y248 L C D S K G A Y L L M E S S P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506833 303 33102 Y248 L C D S K G A Y L L M E A A K
Chicken Gallus gallus XP_414365 303 33320 Y248 L C D I K G S Y L L M D T V Q
Frog Xenopus laevis NP_001087903 309 34182 H248 L C D I R G S H V M I D T I Q
Zebra Danio Brachydanio rerio NP_956591 300 33642 L241 L H G D A D K L C D I R G S R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_798605 323 35764 D236 I C D I K G S D L F F E R S K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P28321 313 35531 V243 N F A K D K P V V I M H G Q D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 39.9 88.8 92.7 N.A. 84.1 83.8 N.A. 86.8 69.9 59.5 56.1 N.A. N.A. N.A. N.A. 37.7
Protein Similarity: 100 41.5 91.4 96.7 N.A. 93.4 92.4 N.A. 95.3 85.1 78.6 70.9 N.A. N.A. N.A. N.A. 51
P-Site Identity: 100 6.6 93.3 93.3 N.A. 80 80 N.A. 93.3 60 26.6 6.6 N.A. N.A. N.A. N.A. 46.6
P-Site Similarity: 100 13.3 93.3 93.3 N.A. 93.3 86.6 N.A. 93.3 80 80 26.6 N.A. N.A. N.A. N.A. 66.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 23.6 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 45 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 9 0 9 9 50 0 0 0 0 0 17 34 0 % A
% Cys: 9 75 0 0 0 0 0 0 9 0 0 0 0 0 0 % C
% Asp: 0 9 75 9 9 9 0 9 0 9 0 17 0 0 9 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 9 59 0 0 0 % E
% Phe: 0 9 0 0 0 0 0 0 0 9 9 0 0 0 0 % F
% Gly: 0 0 9 0 9 75 0 0 0 0 0 0 17 0 0 % G
% His: 0 9 0 0 0 0 0 9 0 0 0 9 0 0 0 % H
% Ile: 9 0 0 25 0 0 0 0 0 9 17 0 0 9 0 % I
% Lys: 0 0 0 17 67 9 9 0 0 0 0 0 0 9 42 % K
% Leu: 75 0 0 0 0 0 0 17 75 59 0 9 9 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 17 67 0 0 0 0 % M
% Asn: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 9 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 17 % Q
% Arg: 0 0 0 0 9 0 0 0 0 0 0 9 9 0 17 % R
% Ser: 0 0 9 50 0 0 25 0 0 0 0 0 34 34 9 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 17 0 0 % T
% Val: 0 0 0 0 0 0 0 9 17 0 0 0 0 9 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 9 59 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _