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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DOK1
All Species:
4.85
Human Site:
S269
Identified Species:
11.85
UniProt:
Q99704
Number Species:
9
Phosphosite Substitution
Charge Score:
0.33
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99704
NP_001372.1
481
52392
S269
H
D
V
L
R
A
D
S
H
E
G
E
V
A
E
Chimpanzee
Pan troglodytes
XP_001161802
481
52376
S269
H
D
V
L
R
A
D
S
Q
E
G
E
V
A
E
Rhesus Macaque
Macaca mulatta
XP_001111248
553
60382
F341
T
A
Q
G
N
D
I
F
Q
A
V
E
T
A
I
Dog
Lupus familis
XP_540216
450
49114
A248
I
F
Q
A
V
E
T
A
I
H
R
Q
K
E
L
Cat
Felis silvestris
Mouse
Mus musculus
P97465
482
52433
D268
A
Q
D
I
L
R
T
D
S
H
D
G
E
T
E
Rat
Rattus norvegicus
Q4QQV2
480
52151
D268
G
Q
D
I
T
R
T
D
S
H
D
G
E
T
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506018
432
47473
E230
G
E
G
S
F
E
F
E
T
R
L
G
N
E
I
Chicken
Gallus gallus
A3R064
426
47148
S224
G
E
G
T
F
T
F
S
T
P
R
A
A
E
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_998253
575
63920
N333
P
M
P
R
G
S
K
N
Q
L
D
E
Q
A
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_394099
524
59294
F276
A
N
L
I
D
I
D
F
S
P
Q
N
S
Q
K
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
79.9
83.1
N.A.
83.6
84.1
N.A.
32.8
32.8
N.A.
35.4
N.A.
N.A.
22.3
N.A.
N.A.
Protein Similarity:
100
99.5
81
87.3
N.A.
88.3
88.5
N.A.
44.7
48.4
N.A.
49.3
N.A.
N.A.
41
N.A.
N.A.
P-Site Identity:
100
93.3
13.3
0
N.A.
6.6
6.6
N.A.
0
6.6
N.A.
13.3
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
100
93.3
13.3
13.3
N.A.
13.3
13.3
N.A.
6.6
13.3
N.A.
26.6
N.A.
N.A.
33.3
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
20
10
0
10
0
20
0
10
0
10
0
10
10
40
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
20
20
0
10
10
30
20
0
0
30
0
0
0
0
% D
% Glu:
0
20
0
0
0
20
0
10
0
20
0
40
20
30
40
% E
% Phe:
0
10
0
0
20
0
20
20
0
0
0
0
0
0
0
% F
% Gly:
30
0
20
10
10
0
0
0
0
0
20
30
0
0
0
% G
% His:
20
0
0
0
0
0
0
0
10
30
0
0
0
0
0
% H
% Ile:
10
0
0
30
0
10
10
0
10
0
0
0
0
0
20
% I
% Lys:
0
0
0
0
0
0
10
0
0
0
0
0
10
0
10
% K
% Leu:
0
0
10
20
10
0
0
0
0
10
10
0
0
0
20
% L
% Met:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
10
0
0
10
0
0
10
0
0
0
10
10
0
0
% N
% Pro:
10
0
10
0
0
0
0
0
0
20
0
0
0
0
0
% P
% Gln:
0
20
20
0
0
0
0
0
30
0
10
10
10
10
0
% Q
% Arg:
0
0
0
10
20
20
0
0
0
10
20
0
0
0
0
% R
% Ser:
0
0
0
10
0
10
0
30
30
0
0
0
10
0
10
% S
% Thr:
10
0
0
10
10
10
30
0
20
0
0
0
10
20
0
% T
% Val:
0
0
20
0
10
0
0
0
0
0
10
0
20
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _