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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMAD5
All Species:
18.18
Human Site:
T221
Identified Species:
36.36
UniProt:
Q99717
Number Species:
11
Phosphosite Substitution
Charge Score:
0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99717
NP_001001419.1
465
52258
T221
P
F
Q
L
P
A
D
T
P
P
P
A
Y
M
P
Chimpanzee
Pan troglodytes
XP_001148109
465
52214
D221
S
P
F
Q
M
P
A
D
T
P
P
P
A
Y
L
Rhesus Macaque
Macaca mulatta
XP_001111602
428
48595
M189
D
T
P
P
P
A
Y
M
P
P
D
D
Q
M
G
Dog
Lupus familis
XP_862707
466
52297
P222
F
Q
L
P
A
D
T
P
P
P
A
Y
M
P
P
Cat
Felis silvestris
Mouse
Mus musculus
P97454
465
52154
T221
P
F
Q
L
P
A
D
T
P
P
P
A
Y
M
P
Rat
Rattus norvegicus
Q9R1V3
465
52197
T221
P
F
Q
L
P
A
D
T
P
P
P
A
Y
M
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510431
465
52196
T221
P
F
Q
L
P
A
D
T
P
P
P
A
Y
M
P
Chicken
Gallus gallus
Q56I99
465
52210
T221
P
F
Q
L
P
A
D
T
P
P
P
A
Y
M
P
Frog
Xenopus laevis
NP_001079973
464
52355
D220
S
P
F
Q
I
P
A
D
T
P
P
P
A
Y
M
Zebra Danio
Brachydanio rerio
Q9W7E7
464
51842
P220
P
S
S
P
F
Q
L
P
A
D
T
P
P
P
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P42003
455
50486
N211
S
S
V
N
S
N
P
N
S
P
Y
D
S
L
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q02330
418
47907
N181
A
N
V
N
F
T
A
N
Q
F
H
Q
Y
N
P
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
89.8
90.9
99.7
N.A.
98.9
99.5
N.A.
97.4
96.7
90.5
91.4
N.A.
73.7
N.A.
51.4
N.A.
Protein Similarity:
100
92.9
91.4
99.7
N.A.
99.1
100
N.A.
99.1
98.4
93.9
95.6
N.A.
82.1
N.A.
64.9
N.A.
P-Site Identity:
100
13.3
33.3
20
N.A.
100
100
N.A.
100
100
13.3
6.6
N.A.
6.6
N.A.
13.3
N.A.
P-Site Similarity:
100
13.3
33.3
20
N.A.
100
100
N.A.
100
100
13.3
6.6
N.A.
13.3
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
0
0
9
50
25
0
9
0
9
42
17
0
17
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
0
0
0
0
9
42
17
0
9
9
17
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
9
42
17
0
17
0
0
0
0
9
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% G
% His:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% H
% Ile:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
9
42
0
0
9
0
0
0
0
0
0
9
9
% L
% Met:
0
0
0
0
9
0
0
9
0
0
0
0
9
50
9
% M
% Asn:
0
9
0
17
0
9
0
17
0
0
0
0
0
9
0
% N
% Pro:
50
17
9
25
50
17
9
17
59
84
59
25
9
17
59
% P
% Gln:
0
9
42
17
0
9
0
0
9
0
0
9
9
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
25
17
9
0
9
0
0
0
9
0
0
0
9
0
0
% S
% Thr:
0
9
0
0
0
9
9
42
17
0
9
0
0
0
0
% T
% Val:
0
0
17
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
9
0
0
0
9
9
50
17
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _