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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CDC6 All Species: 17.27
Human Site: T67 Identified Species: 29.23
UniProt: Q99741 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q99741 NP_001245.1 560 62720 T67 G D D N L C N T P H L P P C S
Chimpanzee Pan troglodytes XP_001170406 560 62717 T67 G D D N L C N T P H L P P C S
Rhesus Macaque Macaca mulatta XP_001096756 559 62520 T67 G D D N L C N T P H L P P C S
Dog Lupus familis XP_537648 559 62507 P67 D D N L C N T P H L P P C S P
Cat Felis silvestris
Mouse Mus musculus O89033 562 62595 T68 G D D N L C N T P R L S P C S
Rat Rattus norvegicus NP_001101768 561 62295 T68 G D D N L C N T P H L S P C S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519126 361 39672
Chicken Gallus gallus
Frog Xenopus laevis NP_001081844 554 60731 I67 G D D N R C N I P P T L S C S
Zebra Danio Brachydanio rerio NP_001120805 561 61262 L87 G D E N G C N L P A S M L G S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_648247 662 75116 L162 H L I S P S R L L D R L S I D
Honey Bee Apis mellifera XP_625142 549 62089 H76 I K N N I N I H D N T I S T Q
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus NP_999666 582 64455 V70 L S P R K R I V A A K E S P V
Poplar Tree Populus trichocarpa XP_002299817 498 55546 V59 R K S P R R C V D S S P N T P
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P09119 513 58018 N70 Q K S S E L V N L N S S D G A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 96 89.1 N.A. 79.5 80 N.A. 45.3 N.A. 63.7 49 N.A. 33.9 36 N.A. 40
Protein Similarity: 100 100 97.5 93.5 N.A. 87.3 88.9 N.A. 52.8 N.A. 77.5 67.3 N.A. 52.1 57.3 N.A. 58.5
P-Site Identity: 100 100 100 13.3 N.A. 86.6 93.3 N.A. 0 N.A. 60 46.6 N.A. 0 6.6 N.A. 0
P-Site Similarity: 100 100 100 20 N.A. 86.6 93.3 N.A. 0 N.A. 60 53.3 N.A. 6.6 26.6 N.A. 0
Percent
Protein Identity: 25.8 N.A. N.A. N.A. 20.1 N.A.
Protein Similarity: 46.4 N.A. N.A. N.A. 41.2 N.A.
P-Site Identity: 6.6 N.A. N.A. N.A. 0 N.A.
P-Site Similarity: 6.6 N.A. N.A. N.A. 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 8 15 0 0 0 0 8 % A
% Cys: 0 0 0 0 8 50 8 0 0 0 0 0 8 43 0 % C
% Asp: 8 58 43 0 0 0 0 0 15 8 0 0 8 0 8 % D
% Glu: 0 0 8 0 8 0 0 0 0 0 0 8 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 50 0 0 0 8 0 0 0 0 0 0 0 0 15 0 % G
% His: 8 0 0 0 0 0 0 8 8 29 0 0 0 0 0 % H
% Ile: 8 0 8 0 8 0 15 8 0 0 0 8 0 8 0 % I
% Lys: 0 22 0 0 8 0 0 0 0 0 8 0 0 0 0 % K
% Leu: 8 8 0 8 36 8 0 15 15 8 36 15 8 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % M
% Asn: 0 0 15 58 0 15 50 8 0 15 0 0 8 0 0 % N
% Pro: 0 0 8 8 8 0 0 8 50 8 8 36 36 8 15 % P
% Gln: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % Q
% Arg: 8 0 0 8 15 15 8 0 0 8 8 0 0 0 0 % R
% Ser: 0 8 15 15 0 8 0 0 0 8 22 22 29 8 50 % S
% Thr: 0 0 0 0 0 0 8 36 0 0 15 0 0 15 0 % T
% Val: 0 0 0 0 0 0 8 15 0 0 0 0 0 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _