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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NPAS2 All Species: 9.09
Human Site: S554 Identified Species: 20
UniProt: Q99743 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q99743 NP_002509.2 824 91761 S554 Q Q P A V S L S F S S T Q R P
Chimpanzee Pan troglodytes XP_515656 1383 151405 S1113 Q Q P A V S L S F S S T Q R P
Rhesus Macaque Macaca mulatta XP_001105763 824 91854 S554 Q Q P A V S L S F S S T Q R P
Dog Lupus familis XP_531781 878 97540 F605 Q D S N M Q M F L Q Q P A G S
Cat Felis silvestris
Mouse Mus musculus P97460 816 90897 V546 C L V Q D S N V Q M F L Q Q P
Rat Rattus norvegicus Q9WVS9 862 96985 N575 Q Q S N P G L N L G S V Q L S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512993 773 87772 E508 G M M H Q L K E Q L E E R T R
Chicken Gallus gallus Q5ZQU2 815 91159 F544 Q D S S V Q M F L Q Q P A V S
Frog Xenopus laevis NP_001083854 825 93251 Q559 Q G I Q M Y L Q Q P A P G L N
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O61735 1027 116123 A723 P G N M T A A A V G N L G A S
Honey Bee Apis mellifera XP_394233 708 81000 A443 S R S K G T S A N S S V A S K
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 59.5 99.2 85 N.A. 87.5 48.7 N.A. 50 73.6 49.7 N.A. N.A. 30.4 36.7 N.A. N.A.
Protein Similarity: 100 59.5 99.3 88.5 N.A. 91.1 63.4 N.A. 64.1 81.8 64.9 N.A. N.A. 45.6 52.6 N.A. N.A.
P-Site Identity: 100 100 100 6.6 N.A. 20 33.3 N.A. 0 13.3 13.3 N.A. N.A. 0 13.3 N.A. N.A.
P-Site Similarity: 100 100 100 20 N.A. 26.6 40 N.A. 6.6 26.6 26.6 N.A. N.A. 20 33.3 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 28 0 10 10 19 0 0 10 0 28 10 0 % A
% Cys: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 19 0 0 10 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 10 0 0 10 10 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 19 28 0 10 0 0 0 0 % F
% Gly: 10 19 0 0 10 10 0 0 0 19 0 0 19 10 0 % G
% His: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 10 0 0 10 0 0 0 0 0 0 0 10 % K
% Leu: 0 10 0 0 0 10 46 0 28 10 0 19 0 19 0 % L
% Met: 0 10 10 10 19 0 19 0 0 10 0 0 0 0 0 % M
% Asn: 0 0 10 19 0 0 10 10 10 0 10 0 0 0 10 % N
% Pro: 10 0 28 0 10 0 0 0 0 10 0 28 0 0 37 % P
% Gln: 64 37 0 19 10 19 0 10 28 19 19 0 46 10 0 % Q
% Arg: 0 10 0 0 0 0 0 0 0 0 0 0 10 28 10 % R
% Ser: 10 0 37 10 0 37 10 28 0 37 46 0 0 10 37 % S
% Thr: 0 0 0 0 10 10 0 0 0 0 0 28 0 10 0 % T
% Val: 0 0 10 0 37 0 0 10 10 0 0 19 0 10 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _