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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIP5K1A
All Species:
22.12
Human Site:
Y437
Identified Species:
54.07
UniProt:
Q99755
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99755
NP_001129108.1
562
62633
Y437
S
V
H
R
P
G
F
Y
A
E
R
F
Q
R
F
Chimpanzee
Pan troglodytes
NP_001131030
550
61213
Y425
S
V
H
R
P
G
F
Y
A
E
R
F
Q
R
F
Rhesus Macaque
Macaca mulatta
NP_001130039
550
61219
Y425
S
V
H
R
P
G
F
Y
A
E
R
F
Q
R
F
Dog
Lupus familis
XP_542172
761
83011
Y529
S
V
H
R
P
S
F
Y
A
E
R
F
F
K
F
Cat
Felis silvestris
Mouse
Mus musculus
P70182
546
60466
R425
R
P
G
F
Y
A
E
R
F
Q
R
F
M
C
N
Rat
Rattus norvegicus
Q5I6B8
688
75576
Y431
S
V
H
R
P
S
F
Y
A
E
R
F
F
K
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511349
767
84935
Y426
S
V
H
R
P
S
F
Y
A
E
R
F
F
K
F
Chicken
Gallus gallus
Q5ZJ58
540
60700
T420
S
I
T
A
L
K
A
T
S
Q
E
I
V
S
A
Frog
Xenopus laevis
Q5PQ01
419
47633
Q299
H
E
V
F
R
A
E
Q
E
E
E
E
E
L
E
Zebra Danio
Brachydanio rerio
Q6IQE1
416
47361
A296
G
E
R
E
E
E
E
A
E
E
P
C
Y
E
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.6
96.9
50.8
N.A.
87.9
53.7
N.A.
49.9
59
26.3
24.2
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
97.6
97.3
60.4
N.A.
93
64
N.A.
60.2
72.5
39.5
39.5
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
80
N.A.
13.3
80
N.A.
80
6.6
6.6
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
86.6
N.A.
20
86.6
N.A.
86.6
26.6
13.3
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
10
0
20
10
10
60
0
0
0
0
0
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
10
0
10
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% D
% Glu:
0
20
0
10
10
10
30
0
20
80
20
10
10
10
10
% E
% Phe:
0
0
0
20
0
0
60
0
10
0
0
70
30
0
60
% F
% Gly:
10
0
10
0
0
30
0
0
0
0
0
0
0
0
0
% G
% His:
10
0
60
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
10
0
0
0
0
0
0
0
0
0
10
0
0
0
% I
% Lys:
0
0
0
0
0
10
0
0
0
0
0
0
0
30
0
% K
% Leu:
0
0
0
0
10
0
0
0
0
0
0
0
0
10
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% N
% Pro:
0
10
0
0
60
0
0
0
0
0
10
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
10
0
20
0
0
30
0
0
% Q
% Arg:
10
0
10
60
10
0
0
10
0
0
70
0
0
30
0
% R
% Ser:
70
0
0
0
0
30
0
0
10
0
0
0
0
10
0
% S
% Thr:
0
0
10
0
0
0
0
10
0
0
0
0
0
0
0
% T
% Val:
0
60
10
0
0
0
0
0
0
0
0
0
10
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
10
0
0
60
0
0
0
0
10
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _