KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP3K3
All Species:
20
Human Site:
S145
Identified Species:
40
UniProt:
Q99759
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99759
NP_002392.2
626
70898
S145
R
Q
V
R
I
K
A
S
Q
S
A
G
D
I
N
Chimpanzee
Pan troglodytes
XP_001137191
630
70979
Q145
K
K
K
K
K
K
N
Q
I
G
L
E
L
L
T
Rhesus Macaque
Macaca mulatta
XP_001116198
646
73052
L165
Q
A
L
S
L
W
P
L
Q
S
M
E
R
L
T
Dog
Lupus familis
XP_537600
626
70813
S145
R
Q
V
R
I
K
A
S
Q
S
A
G
D
I
N
Cat
Felis silvestris
Mouse
Mus musculus
Q61084
626
70757
S145
R
Q
V
R
I
K
P
S
Q
S
A
G
D
I
N
Rat
Rattus norvegicus
NP_001100528
626
70672
S145
R
Q
V
R
V
K
P
S
Q
S
A
G
D
I
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520739
516
56869
S52
D
E
Q
E
A
L
N
S
I
M
K
D
L
V
A
Chicken
Gallus gallus
XP_418076
653
73830
R172
S
G
L
P
K
Q
V
R
I
K
T
S
Q
S
V
Frog
Xenopus laevis
NP_001089288
618
69717
P137
L
Q
P
V
C
P
K
P
H
D
M
R
I
S
K
Zebra Danio
Brachydanio rerio
XP_688694
620
70271
S148
K
Q
V
R
I
K
T
S
Q
S
T
G
D
V
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_782621
389
43041
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P23561
717
80702
T159
L
P
H
E
L
L
A
T
N
S
N
G
E
V
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
66
89.4
97.5
N.A.
96.6
96.3
N.A.
60.2
85.5
61
77.8
N.A.
N.A.
N.A.
N.A.
39.3
Protein Similarity:
100
78.5
90.8
99
N.A.
98.5
98.4
N.A.
65.5
90.9
74.5
85.9
N.A.
N.A.
N.A.
N.A.
48.5
P-Site Identity:
100
6.6
13.3
100
N.A.
93.3
86.6
N.A.
6.6
0
6.6
66.6
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
33.3
40
100
N.A.
93.3
93.3
N.A.
20
13.3
6.6
86.6
N.A.
N.A.
N.A.
N.A.
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
26.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
41.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
0
9
0
25
0
0
0
34
0
0
0
9
% A
% Cys:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
0
0
0
0
0
0
0
0
9
0
9
42
0
0
% D
% Glu:
0
9
0
17
0
0
0
0
0
0
0
17
9
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
9
0
0
0
0
0
0
0
9
0
50
0
0
0
% G
% His:
0
0
9
0
0
0
0
0
9
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
34
0
0
0
25
0
0
0
9
34
0
% I
% Lys:
17
9
9
9
17
50
9
0
0
9
9
0
0
0
9
% K
% Leu:
17
0
17
0
17
17
0
9
0
0
9
0
17
17
0
% L
% Met:
0
0
0
0
0
0
0
0
0
9
17
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
17
0
9
0
9
0
0
0
34
% N
% Pro:
0
9
9
9
0
9
25
9
0
0
0
0
0
0
0
% P
% Gln:
9
50
9
0
0
9
0
9
50
0
0
0
9
0
0
% Q
% Arg:
34
0
0
42
0
0
0
9
0
0
0
9
9
0
0
% R
% Ser:
9
0
0
9
0
0
0
50
0
59
0
9
0
17
9
% S
% Thr:
0
0
0
0
0
0
9
9
0
0
17
0
0
0
25
% T
% Val:
0
0
42
9
9
0
9
0
0
0
0
0
0
25
9
% V
% Trp:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _