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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MAP3K3 All Species: 25.45
Human Site: S237 Identified Species: 50.91
UniProt: Q99759 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q99759 NP_002392.2 626 70898 S237 S L D R S A D S P S F R K S R
Chimpanzee Pan troglodytes XP_001137191 630 70979 G237 S L D S P L D G E S Y P K S R
Rhesus Macaque Macaca mulatta XP_001116198 646 73052 S257 S L D R S A D S P S F R K S R
Dog Lupus familis XP_537600 626 70813 S237 S L D R S A D S P S F R K S R
Cat Felis silvestris
Mouse Mus musculus Q61084 626 70757 S237 S L D R S A D S P S F R K S Q
Rat Rattus norvegicus NP_001100528 626 70672 S237 S L D R S A D S P S F R K S Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520739 516 56869 K144 K N Q D D L D K A I D L L D R
Chicken Gallus gallus XP_418076 653 73830 S264 G S C Q S L D S P S F R K S R
Frog Xenopus laevis NP_001089288 618 69717 E229 Q S L D R S L E S P A F S T P
Zebra Danio Brachydanio rerio XP_688694 620 70271 S240 S L D S N S D S P S L R K S R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_782621 389 43041 G17 V P Q N S Q V G R G M I K G G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P23561 717 80702 G251 N L L A Q N K G I S H N N A E
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 66 89.4 97.5 N.A. 96.6 96.3 N.A. 60.2 85.5 61 77.8 N.A. N.A. N.A. N.A. 39.3
Protein Similarity: 100 78.5 90.8 99 N.A. 98.5 98.4 N.A. 65.5 90.9 74.5 85.9 N.A. N.A. N.A. N.A. 48.5
P-Site Identity: 100 53.3 100 100 N.A. 93.3 93.3 N.A. 13.3 66.6 0 73.3 N.A. N.A. N.A. N.A. 13.3
P-Site Similarity: 100 60 100 100 N.A. 100 100 N.A. 13.3 73.3 13.3 86.6 N.A. N.A. N.A. N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 26.2 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 41.2 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 9 0 42 0 0 9 0 9 0 0 9 0 % A
% Cys: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 59 17 9 0 75 0 0 0 9 0 0 9 0 % D
% Glu: 0 0 0 0 0 0 0 9 9 0 0 0 0 0 9 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 50 9 0 0 0 % F
% Gly: 9 0 0 0 0 0 0 25 0 9 0 0 0 9 9 % G
% His: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 9 9 0 9 0 0 0 % I
% Lys: 9 0 0 0 0 0 9 9 0 0 0 0 75 0 0 % K
% Leu: 0 67 17 0 0 25 9 0 0 0 9 9 9 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % M
% Asn: 9 9 0 9 9 9 0 0 0 0 0 9 9 0 0 % N
% Pro: 0 9 0 0 9 0 0 0 59 9 0 9 0 0 9 % P
% Gln: 9 0 17 9 9 9 0 0 0 0 0 0 0 0 17 % Q
% Arg: 0 0 0 42 9 0 0 0 9 0 0 59 0 0 59 % R
% Ser: 59 17 0 17 59 17 0 59 9 75 0 0 9 67 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % T
% Val: 9 0 0 0 0 0 9 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _