Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MAP3K3 All Species: 33.64
Human Site: T384 Identified Species: 67.27
UniProt: Q99759 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q99759 NP_002392.2 626 70898 T384 Y L C Y D V D T G R E L A S K
Chimpanzee Pan troglodytes XP_001137191 630 70979 T389 Y L C Y D V D T G R E L A V K
Rhesus Macaque Macaca mulatta XP_001116198 646 73052 T404 Y L C Y D V D T G R E L A S K
Dog Lupus familis XP_537600 626 70813 T384 Y L C Y D V D T G R E L A S K
Cat Felis silvestris
Mouse Mus musculus Q61084 626 70757 T384 Y L C Y D V D T G R E L A S K
Rat Rattus norvegicus NP_001100528 626 70672 T384 Y L C Y D V D T G R E L A S K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520739 516 56869 K286 A D S P S F R K S R M S R A Q
Chicken Gallus gallus XP_418076 653 73830 T411 Y L C Y D V D T G R E L A A K
Frog Xenopus laevis NP_001089288 618 69717 T376 Y L C Y D V D T G R E L A V K
Zebra Danio Brachydanio rerio XP_688694 620 70271 A383 V D T G R E L A A K Q V H F D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_782621 389 43041 E159 A V K Q V P T E N S N T D A R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P23561 717 80702 T437 Y L G M N A H T G E L M A V K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 66 89.4 97.5 N.A. 96.6 96.3 N.A. 60.2 85.5 61 77.8 N.A. N.A. N.A. N.A. 39.3
Protein Similarity: 100 78.5 90.8 99 N.A. 98.5 98.4 N.A. 65.5 90.9 74.5 85.9 N.A. N.A. N.A. N.A. 48.5
P-Site Identity: 100 93.3 100 100 N.A. 100 100 N.A. 6.6 93.3 93.3 0 N.A. N.A. N.A. N.A. 0
P-Site Similarity: 100 93.3 100 100 N.A. 100 100 N.A. 20 100 93.3 20 N.A. N.A. N.A. N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. 26.2 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 41.2 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 40 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 53.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 17 0 0 0 0 9 0 9 9 0 0 0 75 25 0 % A
% Cys: 0 0 67 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 17 0 0 67 0 67 0 0 0 0 0 9 0 9 % D
% Glu: 0 0 0 0 0 9 0 9 0 9 67 0 0 0 0 % E
% Phe: 0 0 0 0 0 9 0 0 0 0 0 0 0 9 0 % F
% Gly: 0 0 9 9 0 0 0 0 75 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 9 0 0 0 0 0 9 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 9 0 0 0 0 9 0 9 0 0 0 0 75 % K
% Leu: 0 75 0 0 0 0 9 0 0 0 9 67 0 0 0 % L
% Met: 0 0 0 9 0 0 0 0 0 0 9 9 0 0 0 % M
% Asn: 0 0 0 0 9 0 0 0 9 0 9 0 0 0 0 % N
% Pro: 0 0 0 9 0 9 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 9 0 0 0 0 0 0 9 0 0 0 9 % Q
% Arg: 0 0 0 0 9 0 9 0 0 75 0 0 9 0 9 % R
% Ser: 0 0 9 0 9 0 0 0 9 9 0 9 0 42 0 % S
% Thr: 0 0 9 0 0 0 9 75 0 0 0 9 0 0 0 % T
% Val: 9 9 0 0 9 67 0 0 0 0 0 9 0 25 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 75 0 0 67 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _