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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP3K3
All Species:
13.64
Human Site:
T74
Identified Species:
27.27
UniProt:
Q99759
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99759
NP_002392.2
626
70898
T74
E
D
V
E
H
K
V
T
T
V
F
G
Q
P
L
Chimpanzee
Pan troglodytes
XP_001137191
630
70979
K73
E
D
L
R
S
K
A
K
I
A
F
G
Q
S
M
Rhesus Macaque
Macaca mulatta
XP_001116198
646
73052
I88
E
H
N
G
E
R
R
I
I
A
F
S
R
P
V
Dog
Lupus familis
XP_537600
626
70813
T74
E
D
V
E
H
K
V
T
T
V
F
G
Q
P
L
Cat
Felis silvestris
Mouse
Mus musculus
Q61084
626
70757
T74
E
D
V
E
H
K
V
T
T
V
F
G
Q
P
L
Rat
Rattus norvegicus
NP_001100528
626
70672
T74
E
D
V
E
H
K
V
T
T
V
F
G
Q
P
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520739
516
56869
Chicken
Gallus gallus
XP_418076
653
73830
K105
E
D
V
Q
Q
K
V
K
T
A
F
G
Q
P
L
Frog
Xenopus laevis
NP_001089288
618
69717
Q70
K
V
T
D
A
F
G
Q
T
M
D
L
H
Y
T
Zebra Danio
Brachydanio rerio
XP_688694
620
70271
K77
E
E
V
Q
Q
K
V
K
T
F
F
G
Q
Q
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_782621
389
43041
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P23561
717
80702
N91
D
K
R
I
E
Q
V
N
R
L
K
N
L
M
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
66
89.4
97.5
N.A.
96.6
96.3
N.A.
60.2
85.5
61
77.8
N.A.
N.A.
N.A.
N.A.
39.3
Protein Similarity:
100
78.5
90.8
99
N.A.
98.5
98.4
N.A.
65.5
90.9
74.5
85.9
N.A.
N.A.
N.A.
N.A.
48.5
P-Site Identity:
100
40
20
100
N.A.
100
100
N.A.
0
73.3
6.6
60
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
53.3
40
100
N.A.
100
100
N.A.
0
80
26.6
73.3
N.A.
N.A.
N.A.
N.A.
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
26.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
41.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
9
0
9
0
0
25
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
50
0
9
0
0
0
0
0
0
9
0
0
0
0
% D
% Glu:
67
9
0
34
17
0
0
0
0
0
0
0
0
0
9
% E
% Phe:
0
0
0
0
0
9
0
0
0
9
67
0
0
0
0
% F
% Gly:
0
0
0
9
0
0
9
0
0
0
0
59
0
0
0
% G
% His:
0
9
0
0
34
0
0
0
0
0
0
0
9
0
0
% H
% Ile:
0
0
0
9
0
0
0
9
17
0
0
0
0
0
0
% I
% Lys:
9
9
0
0
0
59
0
25
0
0
9
0
0
0
0
% K
% Leu:
0
0
9
0
0
0
0
0
0
9
0
9
9
0
50
% L
% Met:
0
0
0
0
0
0
0
0
0
9
0
0
0
9
9
% M
% Asn:
0
0
9
0
0
0
0
9
0
0
0
9
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
50
0
% P
% Gln:
0
0
0
17
17
9
0
9
0
0
0
0
59
9
0
% Q
% Arg:
0
0
9
9
0
9
9
0
9
0
0
0
9
0
0
% R
% Ser:
0
0
0
0
9
0
0
0
0
0
0
9
0
9
0
% S
% Thr:
0
0
9
0
0
0
0
34
59
0
0
0
0
0
9
% T
% Val:
0
9
50
0
0
0
59
0
0
34
0
0
0
0
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _