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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ACO2
All Species:
31.52
Human Site:
Y432
Identified Species:
49.52
UniProt:
Q99798
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99798
NP_001089.1
780
85425
Y432
A
T
I
E
R
D
G
Y
A
Q
I
L
R
D
L
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001105023
780
85329
Y432
A
T
I
E
R
D
G
Y
A
Q
I
L
R
D
L
Dog
Lupus familis
XP_849166
781
85703
Y432
A
T
I
E
R
D
G
Y
A
Q
V
L
R
E
V
Cat
Felis silvestris
Mouse
Mus musculus
Q99KI0
780
85445
Y432
A
T
I
E
R
D
G
Y
A
Q
I
L
R
D
V
Rat
Rattus norvegicus
Q9ER34
780
85415
Y432
A
T
I
E
R
D
G
Y
A
Q
I
L
R
D
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516809
792
86180
Y443
A
T
I
E
R
D
G
Y
A
Q
I
L
R
D
V
Chicken
Gallus gallus
Q90875
889
98055
V487
Y
Y
L
R
E
S
G
V
M
S
Y
L
S
Q
L
Frog
Xenopus laevis
NP_001086263
782
85257
Y434
A
T
I
E
R
D
G
Y
A
A
V
L
R
D
V
Zebra Danio
Brachydanio rerio
NP_944590
782
84841
Y434
A
T
I
E
R
D
G
Y
A
K
V
L
R
D
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_524708
787
85380
I440
A
T
I
E
R
D
G
I
S
E
V
F
D
K
F
Honey Bee
Apis mellifera
XP_391994
788
85977
I438
A
T
I
E
R
D
G
I
A
E
I
L
R
K
F
Nematode Worm
Caenorhab. elegans
P34455
777
84028
L429
A
T
I
E
R
D
G
L
S
K
I
F
A
D
F
Sea Urchin
Strong. purpuratus
XP_001176556
783
84215
Q434
A
T
I
E
R
D
G
Q
A
A
T
L
R
E
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q42560
898
98134
L491
K
Y
L
A
K
S
G
L
Q
K
Y
L
N
Q
L
Baker's Yeast
Sacchar. cerevisiae
P19414
778
85350
Q429
A
T
I
E
R
D
G
Q
L
E
T
F
K
E
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.9
96.4
N.A.
96.7
96.4
N.A.
89.5
26.5
87.4
82.9
N.A.
70.9
73.4
73
74.4
Protein Similarity:
100
N.A.
99.4
98.5
N.A.
98.8
98.5
N.A.
93.8
44.4
93.9
90.6
N.A.
81.4
83.8
83.2
85.7
P-Site Identity:
100
N.A.
100
80
N.A.
93.3
93.3
N.A.
93.3
20
80
80
N.A.
46.6
73.3
60
66.6
P-Site Similarity:
100
N.A.
100
100
N.A.
100
100
N.A.
100
26.6
93.3
100
N.A.
66.6
80
73.3
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
27.2
65.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
43.5
79.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
46.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
66.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
87
0
0
7
0
0
0
0
67
14
0
0
7
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
87
0
0
0
0
0
0
7
54
0
% D
% Glu:
0
0
0
87
7
0
0
0
0
20
0
0
0
20
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
20
0
0
34
% F
% Gly:
0
0
0
0
0
0
100
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
87
0
0
0
0
14
0
0
47
0
0
0
0
% I
% Lys:
7
0
0
0
7
0
0
0
0
20
0
0
7
14
0
% K
% Leu:
0
0
14
0
0
0
0
14
7
0
0
80
0
0
27
% L
% Met:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
14
7
40
0
0
0
14
0
% Q
% Arg:
0
0
0
7
87
0
0
0
0
0
0
0
67
0
0
% R
% Ser:
0
0
0
0
0
14
0
0
14
7
0
0
7
0
0
% S
% Thr:
0
87
0
0
0
0
0
0
0
0
14
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
7
0
0
27
0
0
0
40
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
14
0
0
0
0
0
54
0
0
14
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _