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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EPAS1
All Species:
10.3
Human Site:
S435
Identified Species:
22.67
UniProt:
Q99814
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99814
NP_001421.2
870
96459
S435
G
K
A
I
L
P
P
S
Q
P
W
A
T
E
L
Chimpanzee
Pan troglodytes
A2T6X9
766
85495
Q341
D
T
E
Y
K
G
L
Q
L
S
L
D
Q
I
S
Rhesus Macaque
Macaca mulatta
XP_001113007
874
96792
S440
G
K
A
I
L
P
P
S
Q
P
W
A
T
E
L
Dog
Lupus familis
XP_531807
975
107790
S541
N
S
A
L
L
P
P
S
Q
P
W
P
R
E
L
Cat
Felis silvestris
Mouse
Mus musculus
P97481
874
96694
G435
G
K
A
I
L
P
P
G
Q
P
W
V
S
G
L
Rat
Rattus norvegicus
Q9JHS1
874
96700
G435
G
K
A
I
L
P
P
G
Q
P
W
A
T
E
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510942
994
109832
T476
D
S
D
H
L
T
K
T
H
H
D
M
F
T
K
Chicken
Gallus gallus
Q9YIB9
811
90524
L386
D
W
D
D
T
N
S
L
F
E
K
L
K
Q
E
Frog
Xenopus laevis
Q9I8A9
805
90946
L379
M
P
E
I
F
T
E
L
N
E
E
N
N
S
E
Zebra Danio
Brachydanio rerio
Q98SJ5
745
82716
S320
I
V
H
N
S
R
S
S
R
P
H
C
I
V
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24167
1507
165805
S512
I
P
P
V
T
A
T
S
T
A
D
Q
I
K
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
25
96.1
80.2
N.A.
87.7
86
N.A.
39.1
41.9
38.1
26.5
N.A.
20.4
N.A.
N.A.
N.A.
Protein Similarity:
100
44
97.4
84
N.A.
92.1
90.9
N.A.
52.4
58
54.5
43.3
N.A.
33.5
N.A.
N.A.
N.A.
P-Site Identity:
100
0
100
66.6
N.A.
73.3
93.3
N.A.
6.6
0
6.6
13.3
N.A.
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
0
100
73.3
N.A.
80
93.3
N.A.
13.3
6.6
6.6
20
N.A.
20
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
46
0
0
10
0
0
0
10
0
28
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% C
% Asp:
28
0
19
10
0
0
0
0
0
0
19
10
0
0
0
% D
% Glu:
0
0
19
0
0
0
10
0
0
19
10
0
0
37
19
% E
% Phe:
0
0
0
0
10
0
0
0
10
0
0
0
10
0
0
% F
% Gly:
37
0
0
0
0
10
0
19
0
0
0
0
0
10
0
% G
% His:
0
0
10
10
0
0
0
0
10
10
10
0
0
0
0
% H
% Ile:
19
0
0
46
0
0
0
0
0
0
0
0
19
10
0
% I
% Lys:
0
37
0
0
10
0
10
0
0
0
10
0
10
10
10
% K
% Leu:
0
0
0
10
55
0
10
19
10
0
10
10
0
0
46
% L
% Met:
10
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% M
% Asn:
10
0
0
10
0
10
0
0
10
0
0
10
10
0
0
% N
% Pro:
0
19
10
0
0
46
46
0
0
55
0
10
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
10
46
0
0
10
10
10
10
% Q
% Arg:
0
0
0
0
0
10
0
0
10
0
0
0
10
0
0
% R
% Ser:
0
19
0
0
10
0
19
46
0
10
0
0
10
10
19
% S
% Thr:
0
10
0
0
19
19
10
10
10
0
0
0
28
10
0
% T
% Val:
0
10
0
10
0
0
0
0
0
0
0
10
0
10
0
% V
% Trp:
0
10
0
0
0
0
0
0
0
0
46
0
0
0
0
% W
% Tyr:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _