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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TSG101 All Species: 15.15
Human Site: S149 Identified Species: 25.64
UniProt: Q99816 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q99816 NP_006283.1 390 43944 S149 F S R P I S A S Y P P Y Q A T
Chimpanzee Pan troglodytes XP_508319 403 45626 S149 F S R P I S A S Y P P Y Q A T
Rhesus Macaque Macaca mulatta XP_001083004 378 43027 K144 V Y Y F Y N V K K L F L A S Y
Dog Lupus familis XP_542525 391 44074 S150 S R P T I S A S Y P P Y Q A T
Cat Felis silvestris
Mouse Mus musculus Q61187 391 44105 S150 S R P T V S A S Y P P Y T A T
Rat Rattus norvegicus Q6IRE4 391 44059 S150 S R P T V S A S Y P P Y T A A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516719 326 36535 P114 S P Y P P G H P P N P S G Y P
Chicken Gallus gallus
Frog Xenopus laevis NP_001084620 394 44396 M153 T A P A P Y P M Y P A T G P P
Zebra Danio Brachydanio rerio Q6DBY5 471 51246 T165 Y V S N L T I T E G G N R P D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_524120 408 45172 N170 P G A P G G S N S F L P Y P T
Honey Bee Apis mellifera XP_392951 416 46489 P178 H I P G S S F P S Y P Q N S Q
Nematode Worm Caenorhab. elegans NP_500364 425 46214 G187 T P Y P T G S G A A P Y P P S
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LHG8 398 44697 R161 R D P P L Y S R R R P Q P P P
Baker's Yeast Sacchar. cerevisiae P25604 385 43312 E154 E L M S L L H E P P Q D Q A P
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 91 91.5 97.6 N.A. 94.6 93.6 N.A. 62.3 N.A. 82.2 24.6 N.A. 50.7 49 39.5 N.A.
Protein Similarity: 100 92.8 92.5 98.2 N.A. 97.4 96.6 N.A. 68.2 N.A. 90.3 42.8 N.A. 67.8 66.1 58.5 N.A.
P-Site Identity: 100 100 0 73.3 N.A. 60 53.3 N.A. 13.3 N.A. 13.3 0 N.A. 13.3 13.3 20 N.A.
P-Site Similarity: 100 100 13.3 73.3 N.A. 66.6 60 N.A. 13.3 N.A. 20 33.3 N.A. 26.6 20 33.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 30.6 23.8 N.A.
Protein Similarity: N.A. N.A. N.A. 50.2 46.9 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 20 N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 8 8 0 0 36 0 8 8 8 0 8 43 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 8 0 0 0 0 0 0 0 0 0 8 0 0 8 % D
% Glu: 8 0 0 0 0 0 0 8 8 0 0 0 0 0 0 % E
% Phe: 15 0 0 8 0 0 8 0 0 8 8 0 0 0 0 % F
% Gly: 0 8 0 8 8 22 0 8 0 8 8 0 15 0 0 % G
% His: 8 0 0 0 0 0 15 0 0 0 0 0 0 0 0 % H
% Ile: 0 8 0 0 22 0 8 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 8 8 0 0 0 0 0 0 % K
% Leu: 0 8 0 0 22 8 0 0 0 8 8 8 0 0 0 % L
% Met: 0 0 8 0 0 0 0 8 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 8 0 8 0 8 0 8 0 8 8 0 0 % N
% Pro: 8 15 43 43 15 0 8 15 15 50 65 8 15 36 29 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 8 15 29 0 8 % Q
% Arg: 8 22 15 0 0 0 0 8 8 8 0 0 8 0 0 % R
% Ser: 29 15 8 8 8 43 22 36 15 0 0 8 0 15 8 % S
% Thr: 15 0 0 22 8 8 0 8 0 0 0 8 15 0 36 % T
% Val: 8 8 0 0 15 0 8 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 8 22 0 8 15 0 0 43 8 0 43 8 8 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _