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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TSG101 All Species: 21.82
Human Site: S183 Identified Species: 36.92
UniProt: Q99816 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q99816 NP_006283.1 390 43944 S183 S G Y P P N P S G Y P G C P Y
Chimpanzee Pan troglodytes XP_508319 403 45626 S183 S G Y P P N P S G Y P G C P Y
Rhesus Macaque Macaca mulatta XP_001083004 378 43027 Y178 S G Y P G C P Y P P G G P Y P
Dog Lupus familis XP_542525 391 44074 S184 S G Y P P N P S G Y P G C P Y
Cat Felis silvestris
Mouse Mus musculus Q61187 391 44105 S184 S G Y P P N P S G Y P G C P Y
Rat Rattus norvegicus Q6IRE4 391 44059 S184 S G Y P P N P S G Y P G C P Y
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516719 326 36535 T148 P A Q P P G T T V G P A R D G
Chicken Gallus gallus
Frog Xenopus laevis NP_001084620 394 44396 F187 N P S G Y T G F P Y P Q P G Q
Zebra Danio Brachydanio rerio Q6DBY5 471 51246 V199 S I M A K S C V D K L V L I D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_524120 408 45172 G204 P Y P P T P A G P A G G S G Y
Honey Bee Apis mellifera XP_392951 416 46489 Y212 P Y Q G Y G S Y G G T A S N Y
Nematode Worm Caenorhab. elegans NP_500364 425 46214 G221 Q S T P Y P M G A S G A S P Y
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LHG8 398 44697 P195 S L P R P F P P S P Y G G G V
Baker's Yeast Sacchar. cerevisiae P25604 385 43312 H188 P P K P K S P H L K P P L P P
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 91 91.5 97.6 N.A. 94.6 93.6 N.A. 62.3 N.A. 82.2 24.6 N.A. 50.7 49 39.5 N.A.
Protein Similarity: 100 92.8 92.5 98.2 N.A. 97.4 96.6 N.A. 68.2 N.A. 90.3 42.8 N.A. 67.8 66.1 58.5 N.A.
P-Site Identity: 100 100 40 100 N.A. 100 100 N.A. 20 N.A. 13.3 6.6 N.A. 20 13.3 20 N.A.
P-Site Similarity: 100 100 40 100 N.A. 100 100 N.A. 26.6 N.A. 20 13.3 N.A. 20 13.3 20 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 30.6 23.8 N.A.
Protein Similarity: N.A. N.A. N.A. 50.2 46.9 N.A.
P-Site Identity: N.A. N.A. N.A. 26.6 26.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 8 0 0 8 0 8 8 0 22 0 0 0 % A
% Cys: 0 0 0 0 0 8 8 0 0 0 0 0 36 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 8 0 0 0 0 8 8 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 8 0 8 0 0 0 0 0 0 0 % F
% Gly: 0 43 0 15 8 15 8 15 43 15 22 58 8 22 8 % G
% His: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % H
% Ile: 0 8 0 0 0 0 0 0 0 0 0 0 0 8 0 % I
% Lys: 0 0 8 0 15 0 0 0 0 15 0 0 0 0 0 % K
% Leu: 0 8 0 0 0 0 0 0 8 0 8 0 15 0 0 % L
% Met: 0 0 8 0 0 0 8 0 0 0 0 0 0 0 0 % M
% Asn: 8 0 0 0 0 36 0 0 0 0 0 0 0 8 0 % N
% Pro: 29 15 15 72 50 15 58 8 22 15 58 8 15 50 15 % P
% Gln: 8 0 15 0 0 0 0 0 0 0 0 8 0 0 8 % Q
% Arg: 0 0 0 8 0 0 0 0 0 0 0 0 8 0 0 % R
% Ser: 58 8 8 0 0 15 8 36 8 8 0 0 22 0 0 % S
% Thr: 0 0 8 0 8 8 8 8 0 0 8 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 8 8 0 0 8 0 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 15 43 0 22 0 0 15 0 43 8 0 0 8 58 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _