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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMO
All Species:
30.3
Human Site:
S556
Identified Species:
55.56
UniProt:
Q99835
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99835
NP_005622.1
787
86397
S556
W
C
R
L
T
G
Q
S
D
D
E
P
K
R
I
Chimpanzee
Pan troglodytes
XP_519371
786
86255
S555
W
C
R
L
T
G
Q
S
D
D
E
P
K
R
I
Rhesus Macaque
Macaca mulatta
XP_001093150
786
86256
S555
W
C
R
L
T
G
Q
S
D
D
E
P
K
R
I
Dog
Lupus familis
XP_539381
720
80168
P514
R
R
E
L
L
Q
N
P
G
Q
E
L
S
F
S
Cat
Felis silvestris
Mouse
Mus musculus
P56726
793
87281
S560
W
C
R
L
T
G
H
S
D
D
E
P
K
R
I
Rat
Rattus norvegicus
P97698
793
87357
S560
W
C
R
L
T
G
H
S
D
D
E
P
K
R
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509776
697
77420
H507
F
S
M
H
T
V
S
H
D
G
P
V
A
G
L
Chicken
Gallus gallus
O42224
794
88236
S525
W
C
R
L
T
G
Q
S
D
D
Q
P
K
R
I
Frog
Xenopus laevis
NP_001082084
814
91998
S529
W
C
R
I
L
G
R
S
D
D
E
P
K
R
I
Zebra Danio
Brachydanio rerio
NP_571102
822
93043
S535
W
F
R
I
I
G
R
S
D
D
E
P
K
R
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P91682
1036
116534
V579
G
K
E
V
V
E
E
V
K
M
P
K
H
K
V
Honey Bee
Apis mellifera
XP_395373
1059
119629
I640
N
C
E
T
E
E
P
I
R
L
K
K
H
K
V
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781487
550
60898
I360
S
V
S
H
D
D
A
I
G
M
K
L
D
L
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
98.4
85.3
N.A.
92.8
93
N.A.
81.8
77.4
70.1
67.2
N.A.
31.7
33.4
N.A.
32.4
Protein Similarity:
100
99.3
99.1
87.6
N.A.
94.6
94.8
N.A.
84.6
83.5
78.7
77.1
N.A.
46.3
48.5
N.A.
44.7
P-Site Identity:
100
100
100
13.3
N.A.
93.3
93.3
N.A.
13.3
93.3
80
73.3
N.A.
0
6.6
N.A.
0
P-Site Similarity:
100
100
100
13.3
N.A.
93.3
93.3
N.A.
26.6
100
93.3
86.6
N.A.
26.6
26.6
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
8
0
0
0
0
0
8
0
0
% A
% Cys:
0
62
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
8
8
0
0
70
62
0
0
8
0
0
% D
% Glu:
0
0
24
0
8
16
8
0
0
0
62
0
0
0
0
% E
% Phe:
8
8
0
0
0
0
0
0
0
0
0
0
0
8
0
% F
% Gly:
8
0
0
0
0
62
0
0
16
8
0
0
0
8
0
% G
% His:
0
0
0
16
0
0
16
8
0
0
0
0
16
0
0
% H
% Ile:
0
0
0
16
8
0
0
16
0
0
0
0
0
0
62
% I
% Lys:
0
8
0
0
0
0
0
0
8
0
16
16
62
16
0
% K
% Leu:
0
0
0
54
16
0
0
0
0
8
0
16
0
8
8
% L
% Met:
0
0
8
0
0
0
0
0
0
16
0
0
0
0
0
% M
% Asn:
8
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
8
8
0
0
16
62
0
0
8
% P
% Gln:
0
0
0
0
0
8
31
0
0
8
8
0
0
0
0
% Q
% Arg:
8
8
62
0
0
0
16
0
8
0
0
0
0
62
0
% R
% Ser:
8
8
8
0
0
0
8
62
0
0
0
0
8
0
8
% S
% Thr:
0
0
0
8
54
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
8
0
8
8
8
0
8
0
0
0
8
0
0
16
% V
% Trp:
62
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _