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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMO
All Species:
32.42
Human Site:
S588
Identified Species:
59.44
UniProt:
Q99835
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99835
NP_005622.1
787
86397
S588
Q
N
P
G
Q
E
L
S
F
S
M
H
T
V
S
Chimpanzee
Pan troglodytes
XP_519371
786
86255
S587
Q
N
P
G
Q
E
L
S
F
S
M
H
T
V
S
Rhesus Macaque
Macaca mulatta
XP_001093150
786
86256
S587
Q
N
P
G
Q
E
L
S
F
S
M
H
T
V
S
Dog
Lupus familis
XP_539381
720
80168
S546
N
E
P
S
A
D
V
S
S
A
W
A
Q
H
V
Cat
Felis silvestris
Mouse
Mus musculus
P56726
793
87281
S592
Q
N
P
G
Q
E
L
S
F
S
M
H
T
V
S
Rat
Rattus norvegicus
P97698
793
87357
S592
Q
N
P
G
Q
E
L
S
F
S
M
H
T
V
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509776
697
77420
R539
H
V
T
K
M
V
A
R
R
G
A
I
L
P
Q
Chicken
Gallus gallus
O42224
794
88236
S557
R
D
P
G
R
E
L
S
F
S
M
H
T
V
S
Frog
Xenopus laevis
NP_001082084
814
91998
S561
N
N
P
E
K
E
L
S
F
S
L
H
S
V
S
Zebra Danio
Brachydanio rerio
NP_571102
822
93043
S567
K
D
P
E
K
E
L
S
F
S
M
H
T
V
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P91682
1036
116534
H611
S
I
T
L
Y
N
T
H
T
D
P
V
G
L
N
Honey Bee
Apis mellifera
XP_395373
1059
119629
H672
S
I
S
F
H
N
T
H
E
D
P
V
G
L
N
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781487
550
60898
A392
N
V
P
V
R
M
L
A
R
R
G
A
A
Y
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
98.4
85.3
N.A.
92.8
93
N.A.
81.8
77.4
70.1
67.2
N.A.
31.7
33.4
N.A.
32.4
Protein Similarity:
100
99.3
99.1
87.6
N.A.
94.6
94.8
N.A.
84.6
83.5
78.7
77.1
N.A.
46.3
48.5
N.A.
44.7
P-Site Identity:
100
100
100
13.3
N.A.
100
100
N.A.
0
80
66.6
73.3
N.A.
0
0
N.A.
13.3
P-Site Similarity:
100
100
100
33.3
N.A.
100
100
N.A.
0
100
86.6
93.3
N.A.
13.3
13.3
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
0
8
8
0
8
8
16
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
16
0
0
0
8
0
0
0
16
0
0
0
0
0
% D
% Glu:
0
8
0
16
0
62
0
0
8
0
0
0
0
0
0
% E
% Phe:
0
0
0
8
0
0
0
0
62
0
0
0
0
0
0
% F
% Gly:
0
0
0
47
0
0
0
0
0
8
8
0
16
0
0
% G
% His:
8
0
0
0
8
0
0
16
0
0
0
62
0
8
0
% H
% Ile:
0
16
0
0
0
0
0
0
0
0
0
8
0
0
0
% I
% Lys:
8
0
0
8
16
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
8
0
0
70
0
0
0
8
0
8
16
0
% L
% Met:
0
0
0
0
8
8
0
0
0
0
54
0
0
0
0
% M
% Asn:
24
47
0
0
0
16
0
0
0
0
0
0
0
0
16
% N
% Pro:
0
0
77
0
0
0
0
0
0
0
16
0
0
8
8
% P
% Gln:
39
0
0
0
39
0
0
0
0
0
0
0
8
0
8
% Q
% Arg:
8
0
0
0
16
0
0
8
16
8
0
0
0
0
0
% R
% Ser:
16
0
8
8
0
0
0
70
8
62
0
0
8
0
62
% S
% Thr:
0
0
16
0
0
0
16
0
8
0
0
0
54
0
0
% T
% Val:
0
16
0
8
0
8
8
0
0
0
0
16
0
62
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% W
% Tyr:
0
0
0
0
8
0
0
0
0
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _