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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMO
All Species:
25.15
Human Site:
S742
Identified Species:
46.11
UniProt:
Q99835
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99835
NP_005622.1
787
86397
S742
N
P
F
C
P
E
P
S
P
P
Q
D
P
F
L
Chimpanzee
Pan troglodytes
XP_519371
786
86255
S741
N
P
F
C
P
E
P
S
P
P
Q
D
P
F
L
Rhesus Macaque
Macaca mulatta
XP_001093150
786
86256
S741
N
P
F
C
P
E
P
S
P
P
Q
D
P
F
L
Dog
Lupus familis
XP_539381
720
80168
S675
N
P
F
C
P
E
P
S
P
L
Q
D
P
F
L
Cat
Felis silvestris
Mouse
Mus musculus
P56726
793
87281
S748
N
P
F
C
P
E
P
S
P
H
Q
D
P
F
L
Rat
Rattus norvegicus
P97698
793
87357
S748
N
P
F
C
P
E
P
S
P
H
Q
D
P
F
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509776
697
77420
F658
P
G
P
L
Q
D
P
F
L
P
P
P
P
G
P
Chicken
Gallus gallus
O42224
794
88236
G729
N
P
F
C
P
E
S
G
S
P
E
D
E
E
N
Frog
Xenopus laevis
NP_001082084
814
91998
M745
H
P
F
A
A
D
K
M
P
L
T
D
E
S
R
Zebra Danio
Brachydanio rerio
NP_571102
822
93043
S756
N
P
L
T
L
R
D
S
M
Q
G
D
L
S
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P91682
1036
116534
S972
N
P
F
E
L
V
P
S
Y
G
E
D
E
L
Q
Honey Bee
Apis mellifera
XP_395373
1059
119629
A970
D
I
K
L
K
S
D
A
E
I
K
E
V
Y
R
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781487
550
60898
G511
G
G
A
W
G
H
K
G
R
S
L
S
T
I
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
98.4
85.3
N.A.
92.8
93
N.A.
81.8
77.4
70.1
67.2
N.A.
31.7
33.4
N.A.
32.4
Protein Similarity:
100
99.3
99.1
87.6
N.A.
94.6
94.8
N.A.
84.6
83.5
78.7
77.1
N.A.
46.3
48.5
N.A.
44.7
P-Site Identity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
20
53.3
26.6
26.6
N.A.
40
0
N.A.
0
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
26.6
60
40
26.6
N.A.
46.6
33.3
N.A.
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
8
8
0
0
8
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
54
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
0
0
16
16
0
0
0
0
77
0
0
0
% D
% Glu:
0
0
0
8
0
54
0
0
8
0
16
8
24
8
0
% E
% Phe:
0
0
70
0
0
0
0
8
0
0
0
0
0
47
0
% F
% Gly:
8
16
0
0
8
0
0
16
0
8
8
0
0
8
0
% G
% His:
8
0
0
0
0
8
0
0
0
16
0
0
0
0
8
% H
% Ile:
0
8
0
0
0
0
0
0
0
8
0
0
0
8
0
% I
% Lys:
0
0
8
0
8
0
16
0
0
0
8
0
0
0
0
% K
% Leu:
0
0
8
16
16
0
0
0
8
16
8
0
8
8
47
% L
% Met:
0
0
0
0
0
0
0
8
8
0
0
0
0
0
0
% M
% Asn:
70
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% N
% Pro:
8
77
8
0
54
0
62
0
54
39
8
8
54
0
16
% P
% Gln:
0
0
0
0
8
0
0
0
0
8
47
0
0
0
8
% Q
% Arg:
0
0
0
0
0
8
0
0
8
0
0
0
0
0
16
% R
% Ser:
0
0
0
0
0
8
8
62
8
8
0
8
0
16
0
% S
% Thr:
0
0
0
8
0
0
0
0
0
0
8
0
8
0
0
% T
% Val:
0
0
0
0
0
8
0
0
0
0
0
0
8
0
0
% V
% Trp:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
8
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _