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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMO
All Species:
31.82
Human Site:
T593
Identified Species:
58.33
UniProt:
Q99835
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99835
NP_005622.1
787
86397
T593
E
L
S
F
S
M
H
T
V
S
H
D
G
P
V
Chimpanzee
Pan troglodytes
XP_519371
786
86255
T592
E
L
S
F
S
M
H
T
V
S
H
D
G
P
V
Rhesus Macaque
Macaca mulatta
XP_001093150
786
86256
T592
E
L
S
F
S
M
H
T
V
S
H
D
G
P
V
Dog
Lupus familis
XP_539381
720
80168
Q551
D
V
S
S
A
W
A
Q
H
V
T
K
M
V
A
Cat
Felis silvestris
Mouse
Mus musculus
P56726
793
87281
T597
E
L
S
F
S
M
H
T
V
S
H
D
G
P
V
Rat
Rattus norvegicus
P97698
793
87357
T597
E
L
S
F
S
M
H
T
V
S
H
D
G
P
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509776
697
77420
L544
V
A
R
R
G
A
I
L
P
Q
D
V
S
V
T
Chicken
Gallus gallus
O42224
794
88236
T562
E
L
S
F
S
M
H
T
V
S
H
D
G
P
V
Frog
Xenopus laevis
NP_001082084
814
91998
S566
E
L
S
F
S
L
H
S
V
S
H
E
G
P
V
Zebra Danio
Brachydanio rerio
NP_571102
822
93043
T572
E
L
S
F
S
M
H
T
V
S
H
E
G
P
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P91682
1036
116534
G616
N
T
H
T
D
P
V
G
L
N
F
D
V
N
D
Honey Bee
Apis mellifera
XP_395373
1059
119629
G677
N
T
H
E
D
P
V
G
L
N
F
D
L
N
S
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781487
550
60898
A397
M
L
A
R
R
G
A
A
Y
P
I
A
T
I
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
98.4
85.3
N.A.
92.8
93
N.A.
81.8
77.4
70.1
67.2
N.A.
31.7
33.4
N.A.
32.4
Protein Similarity:
100
99.3
99.1
87.6
N.A.
94.6
94.8
N.A.
84.6
83.5
78.7
77.1
N.A.
46.3
48.5
N.A.
44.7
P-Site Identity:
100
100
100
6.6
N.A.
100
100
N.A.
0
100
80
93.3
N.A.
6.6
6.6
N.A.
6.6
P-Site Similarity:
100
100
100
26.6
N.A.
100
100
N.A.
0
100
100
100
N.A.
20
20
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
8
0
8
8
16
8
0
0
0
8
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
0
16
0
0
0
0
0
8
62
0
0
8
% D
% Glu:
62
0
0
8
0
0
0
0
0
0
0
16
0
0
0
% E
% Phe:
0
0
0
62
0
0
0
0
0
0
16
0
0
0
0
% F
% Gly:
0
0
0
0
8
8
0
16
0
0
0
0
62
0
8
% G
% His:
0
0
16
0
0
0
62
0
8
0
62
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
8
0
0
0
8
0
0
8
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% K
% Leu:
0
70
0
0
0
8
0
8
16
0
0
0
8
0
0
% L
% Met:
8
0
0
0
0
54
0
0
0
0
0
0
8
0
0
% M
% Asn:
16
0
0
0
0
0
0
0
0
16
0
0
0
16
0
% N
% Pro:
0
0
0
0
0
16
0
0
8
8
0
0
0
62
0
% P
% Gln:
0
0
0
0
0
0
0
8
0
8
0
0
0
0
0
% Q
% Arg:
0
0
8
16
8
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
70
8
62
0
0
8
0
62
0
0
8
0
8
% S
% Thr:
0
16
0
8
0
0
0
54
0
0
8
0
8
0
8
% T
% Val:
8
8
0
0
0
0
16
0
62
8
0
8
8
16
62
% V
% Trp:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _