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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MYD88
All Species:
25.45
Human Site:
Y187
Identified Species:
56
UniProt:
Q99836
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99836
NP_002459.2
296
33233
Y187
R
Q
L
E
Q
T
N
Y
R
L
K
L
C
V
S
Chimpanzee
Pan troglodytes
B3Y678
296
33252
Y187
R
Q
L
E
Q
T
N
Y
R
L
K
L
C
V
S
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_534223
296
33525
Y187
R
Q
L
E
Q
T
N
Y
R
L
K
L
C
V
S
Cat
Felis silvestris
Mouse
Mus musculus
P22366
296
33734
Y187
R
Q
L
E
Q
T
D
Y
R
L
K
L
C
V
S
Rat
Rattus norvegicus
Q6Y1S1
296
33837
Y187
R
Q
L
E
Q
T
D
Y
R
L
K
L
C
V
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508351
185
21183
G77
Q
L
E
Q
T
E
F
G
L
K
L
C
V
S
D
Chicken
Gallus gallus
A5HNF6
299
33763
F190
R
E
L
E
Q
T
E
F
K
L
K
L
C
V
F
Frog
Xenopus laevis
Q9DF60
283
32811
Y175
S
R
L
E
Q
T
D
Y
K
L
K
L
C
V
F
Zebra Danio
Brachydanio rerio
Q5XJ85
284
32856
Y175
K
Q
L
E
H
T
E
Y
N
L
K
L
C
V
F
Tiger Blowfish
Takifugu rubipres
NP_001106666
288
33226
F179
R
Q
L
E
E
T
D
F
K
L
K
L
C
V
F
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780590
367
41216
E258
L
R
S
Q
L
E
S
E
P
H
N
Y
K
L
C
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
N.A.
91.2
N.A.
81.7
81.7
N.A.
54.7
71.5
59.7
60.4
59.1
N.A.
N.A.
N.A.
35.4
Protein Similarity:
100
99.3
N.A.
93.5
N.A.
87.8
87.8
N.A.
58.7
82.2
72.3
71.9
74.6
N.A.
N.A.
N.A.
53.6
P-Site Identity:
100
100
N.A.
100
N.A.
93.3
93.3
N.A.
0
66.6
66.6
66.6
66.6
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
100
N.A.
100
N.A.
100
100
N.A.
13.3
86.6
86.6
73.3
93.3
N.A.
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
10
82
0
10
% C
% Asp:
0
0
0
0
0
0
37
0
0
0
0
0
0
0
10
% D
% Glu:
0
10
10
82
10
19
19
10
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
10
19
0
0
0
0
0
0
37
% F
% Gly:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
10
0
0
0
0
10
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
10
0
0
0
0
0
0
0
28
10
82
0
10
0
0
% K
% Leu:
10
10
82
0
10
0
0
0
10
82
10
82
0
10
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
28
0
10
0
10
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% P
% Gln:
10
64
0
19
64
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
64
19
0
0
0
0
0
0
46
0
0
0
0
0
0
% R
% Ser:
10
0
10
0
0
0
10
0
0
0
0
0
0
10
46
% S
% Thr:
0
0
0
0
10
82
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
10
82
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
64
0
0
0
10
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _