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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PTPN18 All Species: 35.15
Human Site: Y281 Identified Species: 85.93
UniProt: Q99952 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q99952 NP_055184.2 460 50482 Y281 A V Q T E E Q Y R F L Y H T V
Chimpanzee Pan troglodytes XP_513663 807 91678 Y279 L V Q T Q E Q Y E L V Y N A V
Rhesus Macaque Macaca mulatta XP_001093333 456 50339 Y281 A V Q T E E Q Y R F L Y H T V
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q61152 453 50183 Y281 A V Q T E E Q Y R F L Y H T V
Rat Rattus norvegicus NP_001013129 453 50088 Y281 A V Q T E E Q Y R F L Y H T V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521024 682 72925 Y450 A V Q T Q E Q Y K F V Y H I V
Chicken Gallus gallus XP_001235234 775 85980 Y279 I V Q T K E Q Y K L V Y N A V
Frog Xenopus laevis NP_001121240 511 57423 Y282 A I Q T R E Q Y E F L Y H A V
Zebra Danio Brachydanio rerio NP_001013470 513 57261 Y281 A V Q T K E Q Y G F V F H T V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_796904 967 106580 Y285 I V Q T R N Q Y E L V H R A V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 27.1 94.7 N.A. N.A. 75.8 74.7 N.A. 36.5 27.6 42.2 39.1 N.A. N.A. N.A. N.A. 22.6
Protein Similarity: 100 38.7 96.5 N.A. N.A. 82.6 82.3 N.A. 46.9 40.6 58.7 55.3 N.A. N.A. N.A. N.A. 32.4
P-Site Identity: 100 53.3 100 N.A. N.A. 100 100 N.A. 73.3 53.3 73.3 73.3 N.A. N.A. N.A. N.A. 40
P-Site Similarity: 100 73.3 100 N.A. N.A. 100 100 N.A. 93.3 80 80 93.3 N.A. N.A. N.A. N.A. 53.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 70 0 0 0 0 0 0 0 0 0 0 0 0 40 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 40 90 0 0 30 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 70 0 10 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 10 70 0 0 % H
% Ile: 20 10 0 0 0 0 0 0 0 0 0 0 0 10 0 % I
% Lys: 0 0 0 0 20 0 0 0 20 0 0 0 0 0 0 % K
% Leu: 10 0 0 0 0 0 0 0 0 30 50 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 10 0 0 0 0 0 0 20 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 100 0 20 0 100 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 20 0 0 0 40 0 0 0 10 0 0 % R
% Ser: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 100 0 0 0 0 0 0 0 0 0 50 0 % T
% Val: 0 90 0 0 0 0 0 0 0 0 50 0 0 0 100 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 100 0 0 0 80 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _