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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PTPN18 All Species: 5.15
Human Site: Y389 Identified Species: 12.59
UniProt: Q99952 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q99952 NP_055184.2 460 50482 Y389 S A E E A P L Y S K V T P R A
Chimpanzee Pan troglodytes XP_513663 807 91678 L586 N S N D S L S L N S P T N I S
Rhesus Macaque Macaca mulatta XP_001093333 456 50339 T389 V P L Y S Q V T P R A Q R P G
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q61152 453 50183 Q389 S Q V A P R A Q R P V A H T E
Rat Rattus norvegicus NP_001013129 453 50088 Q389 S Q V A P R I Q R P V S H T E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521024 682 72925 T560 E P Q Y D N V T A G G S A P A
Chicken Gallus gallus XP_001235234 775 85980 D422 S S E Q L L L D L E L Q G T G
Frog Xenopus laevis NP_001121240 511 57423 Y405 P T P Q N Q L Y S T V T P K S
Zebra Danio Brachydanio rerio NP_001013470 513 57261 K393 S A V Y S T V K P K T R P V S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_796904 967 106580 D693 S V Q S S G S D S R S S R K N
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 27.1 94.7 N.A. N.A. 75.8 74.7 N.A. 36.5 27.6 42.2 39.1 N.A. N.A. N.A. N.A. 22.6
Protein Similarity: 100 38.7 96.5 N.A. N.A. 82.6 82.3 N.A. 46.9 40.6 58.7 55.3 N.A. N.A. N.A. N.A. 32.4
P-Site Identity: 100 6.6 0 N.A. N.A. 13.3 13.3 N.A. 6.6 20 40 26.6 N.A. N.A. N.A. N.A. 13.3
P-Site Similarity: 100 46.6 20 N.A. N.A. 13.3 26.6 N.A. 33.3 46.6 60 46.6 N.A. N.A. N.A. N.A. 46.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 20 0 20 10 0 10 0 10 0 10 10 10 0 20 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 10 10 0 0 20 0 0 0 0 0 0 0 % D
% Glu: 10 0 20 10 0 0 0 0 0 10 0 0 0 0 20 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 10 0 0 0 10 10 0 10 0 20 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 20 0 0 % H
% Ile: 0 0 0 0 0 0 10 0 0 0 0 0 0 10 0 % I
% Lys: 0 0 0 0 0 0 0 10 0 20 0 0 0 20 0 % K
% Leu: 0 0 10 0 10 20 30 10 10 0 10 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 10 0 10 0 10 10 0 0 10 0 0 0 10 0 10 % N
% Pro: 10 20 10 0 20 10 0 0 20 20 10 0 30 20 0 % P
% Gln: 0 20 20 20 0 20 0 20 0 0 0 20 0 0 0 % Q
% Arg: 0 0 0 0 0 20 0 0 20 20 0 10 20 10 0 % R
% Ser: 60 20 0 10 40 0 20 0 30 10 10 30 0 0 30 % S
% Thr: 0 10 0 0 0 10 0 20 0 10 10 30 0 30 0 % T
% Val: 10 10 30 0 0 0 30 0 0 0 40 0 0 10 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 30 0 0 0 20 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _