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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
VRK1
All Species:
16.97
Human Site:
T378
Identified Species:
31.11
UniProt:
Q99986
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99986
NP_003375.1
396
45476
T378
E
D
T
E
W
S
N
T
Q
T
E
E
A
I
Q
Chimpanzee
Pan troglodytes
XP_510157
396
45456
T378
E
D
V
E
W
S
N
T
Q
T
E
E
A
I
Q
Rhesus Macaque
Macaca mulatta
XP_001102618
396
45467
T378
E
D
M
E
W
S
D
T
Q
T
E
E
A
I
Q
Dog
Lupus familis
XP_547970
395
44398
S378
T
G
V
Q
L
S
E
S
G
C
T
H
V
K
A
Cat
Felis silvestris
Mouse
Mus musculus
Q80X41
440
49722
T378
E
D
M
E
C
S
D
T
Q
V
Q
E
A
A
Q
Rat
Rattus norvegicus
P97633
325
37477
Q308
L
K
Q
K
A
A
Q
Q
A
A
S
S
S
G
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512207
479
54436
P377
W
F
S
S
S
S
P
P
R
L
G
E
F
N
F
Chicken
Gallus gallus
NP_001006485
413
46937
S377
A
E
M
E
D
A
G
S
P
E
K
K
K
P
A
Frog
Xenopus laevis
NP_001080108
438
49973
I416
E
E
A
N
A
Q
W
I
N
R
E
D
F
E
E
Zebra Danio
Brachydanio rerio
Q7ZUS1
425
47752
K379
T
D
S
T
P
A
K
K
R
R
A
P
Q
K
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q7KRY6
599
65975
S390
L
D
E
K
I
S
A
S
E
D
D
E
E
E
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_783182
473
53072
P384
G
P
S
G
A
A
S
P
R
A
A
P
P
K
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P23292
546
62061
P468
R
E
A
S
K
L
D
P
T
S
Y
E
A
Y
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
98.2
83.8
N.A.
76.8
29
N.A.
66.1
70.2
47.2
59.2
N.A.
31
N.A.
N.A.
39.7
Protein Similarity:
100
99.7
98.9
88.1
N.A.
83.4
46.4
N.A.
73
81.5
59.3
72.4
N.A.
43.7
N.A.
N.A.
56
P-Site Identity:
100
93.3
86.6
6.6
N.A.
60
6.6
N.A.
13.3
6.6
13.3
6.6
N.A.
20
N.A.
N.A.
0
P-Site Similarity:
100
93.3
93.3
20
N.A.
73.3
26.6
N.A.
26.6
40
33.3
33.3
N.A.
53.3
N.A.
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
20.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
37.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
16
0
24
31
8
0
8
16
16
0
39
8
16
% A
% Cys:
0
0
0
0
8
0
0
0
0
8
0
0
0
0
0
% C
% Asp:
0
47
0
0
8
0
24
0
0
8
8
8
0
0
0
% D
% Glu:
39
24
8
39
0
0
8
0
8
8
31
54
8
16
16
% E
% Phe:
0
8
0
0
0
0
0
0
0
0
0
0
16
0
8
% F
% Gly:
8
8
0
8
0
0
8
0
8
0
8
0
0
8
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% H
% Ile:
0
0
0
0
8
0
0
8
0
0
0
0
0
24
0
% I
% Lys:
0
8
0
16
8
0
8
8
0
0
8
8
8
24
16
% K
% Leu:
16
0
0
0
8
8
0
0
0
8
0
0
0
0
0
% L
% Met:
0
0
24
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
8
0
0
16
0
8
0
0
0
0
8
0
% N
% Pro:
0
8
0
0
8
0
8
24
8
0
0
16
8
8
0
% P
% Gln:
0
0
8
8
0
8
8
8
31
0
8
0
8
0
47
% Q
% Arg:
8
0
0
0
0
0
0
0
24
16
0
0
0
0
0
% R
% Ser:
0
0
24
16
8
54
8
24
0
8
8
8
8
0
0
% S
% Thr:
16
0
8
8
0
0
0
31
8
24
8
0
0
0
0
% T
% Val:
0
0
16
0
0
0
0
0
0
8
0
0
8
0
0
% V
% Trp:
8
0
0
0
24
0
8
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
8
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _