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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
VRK1
All Species:
43.03
Human Site:
Y173
Identified Species:
78.89
UniProt:
Q99986
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99986
NP_003375.1
396
45476
Y173
E
Y
I
H
E
H
E
Y
V
H
G
D
I
K
A
Chimpanzee
Pan troglodytes
XP_510157
396
45456
Y173
E
Y
I
H
E
H
E
Y
V
H
G
D
I
K
A
Rhesus Macaque
Macaca mulatta
XP_001102618
396
45467
Y173
E
Y
I
H
E
H
E
Y
V
H
G
D
I
K
A
Dog
Lupus familis
XP_547970
395
44398
Y173
E
Y
I
H
E
H
E
Y
V
H
G
D
I
K
A
Cat
Felis silvestris
Mouse
Mus musculus
Q80X41
440
49722
Y173
E
Y
I
H
E
H
E
Y
V
H
G
D
I
K
A
Rat
Rattus norvegicus
P97633
325
37477
R107
L
F
N
F
C
S
R
R
F
T
M
K
T
V
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512207
479
54436
Y172
E
Y
I
H
E
H
E
Y
V
H
G
D
I
K
A
Chicken
Gallus gallus
NP_001006485
413
46937
Y172
E
Y
I
H
E
H
E
Y
V
H
G
D
I
K
A
Frog
Xenopus laevis
NP_001080108
438
49973
Y162
E
F
I
H
E
N
E
Y
V
H
C
D
I
K
A
Zebra Danio
Brachydanio rerio
Q7ZUS1
425
47752
Y174
E
Y
I
H
D
H
E
Y
V
H
A
D
I
K
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q7KRY6
599
65975
Y179
Q
Y
M
H
S
N
G
Y
V
H
A
D
L
K
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_783182
473
53072
Y166
E
Y
L
H
E
M
N
Y
V
H
A
D
I
K
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P23292
546
62061
R194
H
A
H
D
L
I
Y
R
D
I
K
P
D
N
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
98.2
83.8
N.A.
76.8
29
N.A.
66.1
70.2
47.2
59.2
N.A.
31
N.A.
N.A.
39.7
Protein Similarity:
100
99.7
98.9
88.1
N.A.
83.4
46.4
N.A.
73
81.5
59.3
72.4
N.A.
43.7
N.A.
N.A.
56
P-Site Identity:
100
100
100
100
N.A.
100
0
N.A.
100
100
80
86.6
N.A.
53.3
N.A.
N.A.
66.6
P-Site Similarity:
100
100
100
100
N.A.
100
6.6
N.A.
100
100
93.3
93.3
N.A.
80
N.A.
N.A.
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
20.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
37.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
0
0
0
0
0
24
0
0
0
77
% A
% Cys:
0
0
0
0
8
0
0
0
0
0
8
0
0
0
0
% C
% Asp:
0
0
0
8
8
0
0
0
8
0
0
85
8
0
0
% D
% Glu:
77
0
0
0
70
0
70
0
0
0
0
0
0
0
0
% E
% Phe:
0
16
0
8
0
0
0
0
8
0
0
0
0
0
8
% F
% Gly:
0
0
0
0
0
0
8
0
0
0
54
0
0
0
0
% G
% His:
8
0
8
85
0
62
0
0
0
85
0
0
0
0
0
% H
% Ile:
0
0
70
0
0
8
0
0
0
8
0
0
77
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
8
8
0
85
0
% K
% Leu:
8
0
8
0
8
0
0
0
0
0
0
0
8
0
8
% L
% Met:
0
0
8
0
0
8
0
0
0
0
8
0
0
0
0
% M
% Asn:
0
0
8
0
0
16
8
0
0
0
0
0
0
8
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% P
% Gln:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
8
16
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
8
8
0
0
0
0
0
0
0
0
8
% S
% Thr:
0
0
0
0
0
0
0
0
0
8
0
0
8
0
0
% T
% Val:
0
0
0
0
0
0
0
0
85
0
0
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
77
0
0
0
0
8
85
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _