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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GDF15
All Species:
8.79
Human Site:
S146
Identified Species:
17.58
UniProt:
Q99988
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99988
NP_004855.2
308
34154
S146
R
P
L
R
R
Q
L
S
L
A
R
P
Q
A
P
Chimpanzee
Pan troglodytes
XP_524157
308
34168
S146
R
P
L
R
R
Q
L
S
L
A
R
P
Q
A
P
Rhesus Macaque
Macaca mulatta
XP_001114375
308
34522
R146
R
P
L
R
R
Q
L
R
L
A
R
P
Q
A
P
Dog
Lupus familis
XP_541938
307
33972
S148
R
P
L
Q
R
Q
L
S
R
V
G
S
R
T
P
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z0J7
303
33238
L147
P
L
K
R
A
L
S
L
Q
G
P
R
A
P
A
Rat
Rattus norvegicus
Q9Z0J6
303
33420
L147
P
L
Q
R
A
I
S
L
Q
G
P
H
A
R
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508533
404
44634
P200
R
F
L
S
K
R
R
P
H
I
Q
A
Y
L
L
Chicken
Gallus gallus
XP_001236632
180
20074
G47
N
D
A
N
P
E
R
G
Y
F
S
E
N
R
T
Frog
Xenopus laevis
P30886
426
48946
F149
K
N
S
Y
R
Q
K
F
K
F
D
L
T
D
I
Zebra Danio
Brachydanio rerio
P35621
355
40183
H204
Q
L
E
L
Q
V
M
H
L
N
N
M
L
H
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07713
588
65849
T326
K
A
A
E
L
Q
L
T
R
D
A
L
S
Q
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_504709
365
41750
D225
A
P
L
I
V
F
S
D
L
S
E
P
S
S
V
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
96.4
91.8
63.6
N.A.
60
59
N.A.
31.9
27.2
20.6
21.6
N.A.
20.9
N.A.
23.5
N.A.
Protein Similarity:
100
98.3
95.7
75
N.A.
74.6
73
N.A.
46
36.6
36.3
39.7
N.A.
31.9
N.A.
38.9
N.A.
P-Site Identity:
100
100
93.3
53.3
N.A.
6.6
6.6
N.A.
13.3
0
13.3
6.6
N.A.
13.3
N.A.
26.6
N.A.
P-Site Similarity:
100
100
93.3
66.6
N.A.
6.6
6.6
N.A.
33.3
6.6
20
26.6
N.A.
26.6
N.A.
40
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
9
17
0
17
0
0
0
0
25
9
9
17
25
17
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
9
0
0
0
0
0
9
0
9
9
0
0
9
9
% D
% Glu:
0
0
9
9
0
9
0
0
0
0
9
9
0
0
0
% E
% Phe:
0
9
0
0
0
9
0
9
0
17
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
9
0
17
9
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
9
9
0
0
9
0
9
0
% H
% Ile:
0
0
0
9
0
9
0
0
0
9
0
0
0
0
9
% I
% Lys:
17
0
9
0
9
0
9
0
9
0
0
0
0
0
0
% K
% Leu:
0
25
50
9
9
9
42
17
42
0
0
17
9
9
9
% L
% Met:
0
0
0
0
0
0
9
0
0
0
0
9
0
0
0
% M
% Asn:
9
9
0
9
0
0
0
0
0
9
9
0
9
0
0
% N
% Pro:
17
42
0
0
9
0
0
9
0
0
17
34
0
9
34
% P
% Gln:
9
0
9
9
9
50
0
0
17
0
9
0
25
9
9
% Q
% Arg:
42
0
0
42
42
9
17
9
17
0
25
9
9
17
0
% R
% Ser:
0
0
9
9
0
0
25
25
0
9
9
9
17
9
0
% S
% Thr:
0
0
0
0
0
0
0
9
0
0
0
0
9
9
9
% T
% Val:
0
0
0
0
9
9
0
0
0
9
0
0
0
0
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
9
0
0
0
0
9
0
0
0
9
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _