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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DPH2 All Species: 8.48
Human Site: S425 Identified Species: 13.33
UniProt: Q9BQC3 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9BQC3 NP_001375.2 489 52083 S425 R P P P A W K S S N D H G S L
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_532611 487 51822 P423 R P P P A W K P S N D P G C L
Cat Felis silvestris
Mouse Mus musculus Q9CR25 489 52346 S425 R P P P P W K S S D D T R C S
Rat Rattus norvegicus Q568Y2 489 52306 S425 R P P P P W K S S D D T K C S
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q5ZKI2 477 52145 P411 H L C D P L A P Q P P S S T T
Frog Xenopus laevis Q6DE00 478 52667 L414 H L T V A E T L E K D S D T S
Zebra Danio Brachydanio rerio A4QN59 498 55134 M426 S T N S S E M M H N S E T S S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_650402 469 52077 L399 V S L V S G R L R G A V N D S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q09454 476 52936 L411 K A A G D F S L I S G K V R V
Sea Urchin Strong. purpuratus XP_786110 552 60545 R489 G D N R L M G R S C D A G A L
Poplar Tree Populus trichocarpa XP_002326199 496 54716 N423 Q E K K E E E N E G V L A L A
Maize Zea mays NP_001146073 514 56668 T447 S L A L A E V T E K A L S I Q
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_191522 491 54825 D419 Q A K N G E E D T G E T M T L
Baker's Yeast Sacchar. cerevisiae P32461 534 59757 T424 Q D T I S A S T T S D E P E F
Red Bread Mold Neurospora crassa Q7S5C0 602 65317 E520 K P K S A K K E D S S D K P D
Conservation
Percent
Protein Identity: 100 N.A. N.A. 88.3 N.A. 83.6 84.8 N.A. N.A. 47.4 44.3 38.7 N.A. 29.6 N.A. 29.8 35.5
Protein Similarity: 100 N.A. N.A. 91.6 N.A. 88.9 89.5 N.A. N.A. 60.3 61.1 56.6 N.A. 47.6 N.A. 48.2 51.2
P-Site Identity: 100 N.A. N.A. 80 N.A. 60 60 N.A. N.A. 0 13.3 13.3 N.A. 0 N.A. 0 26.6
P-Site Similarity: 100 N.A. N.A. 80 N.A. 66.6 66.6 N.A. N.A. 6.6 20 20 N.A. 13.3 N.A. 26.6 33.3
Percent
Protein Identity: 27 26 N.A. 26.2 25.6 24.7
Protein Similarity: 44.1 43.3 N.A. 45.2 40.8 37.2
P-Site Identity: 0 6.6 N.A. 6.6 6.6 20
P-Site Similarity: 20 13.3 N.A. 40 40 33.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 14 14 0 34 7 7 0 0 0 14 7 7 7 7 % A
% Cys: 0 0 7 0 0 0 0 0 0 7 0 0 0 20 0 % C
% Asp: 0 14 0 7 7 0 0 7 7 14 47 7 7 7 7 % D
% Glu: 0 7 0 0 7 34 14 7 20 0 7 14 0 7 0 % E
% Phe: 0 0 0 0 0 7 0 0 0 0 0 0 0 0 7 % F
% Gly: 7 0 0 7 7 7 7 0 0 20 7 0 20 0 0 % G
% His: 14 0 0 0 0 0 0 0 7 0 0 7 0 0 0 % H
% Ile: 0 0 0 7 0 0 0 0 7 0 0 0 0 7 0 % I
% Lys: 14 0 20 7 0 7 34 0 0 14 0 7 14 0 0 % K
% Leu: 0 20 7 7 7 7 0 20 0 0 0 14 0 7 27 % L
% Met: 0 0 0 0 0 7 7 7 0 0 0 0 7 0 0 % M
% Asn: 0 0 14 7 0 0 0 7 0 20 0 0 7 0 0 % N
% Pro: 0 34 27 27 20 0 0 14 0 7 7 7 7 7 0 % P
% Gln: 20 0 0 0 0 0 0 0 7 0 0 0 0 0 7 % Q
% Arg: 27 0 0 7 0 0 7 7 7 0 0 0 7 7 0 % R
% Ser: 14 7 0 14 20 0 14 20 34 20 14 14 14 14 34 % S
% Thr: 0 7 14 0 0 0 7 14 14 0 0 20 7 20 7 % T
% Val: 7 0 0 14 0 0 7 0 0 0 7 7 7 0 7 % V
% Trp: 0 0 0 0 0 27 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _