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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLCD4
All Species:
6.06
Human Site:
S457
Identified Species:
10.26
UniProt:
Q9BRC7
Number Species:
13
Phosphosite Substitution
Charge Score:
0.31
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9BRC7
NP_116115.1
762
87585
S457
A
E
P
E
L
E
E
S
E
L
A
L
E
S
Q
Chimpanzee
Pan troglodytes
XP_526029
762
87514
S457
A
E
P
E
L
E
E
S
E
L
A
L
E
S
Q
Rhesus Macaque
Macaca mulatta
XP_001091488
799
91444
E457
V
E
P
G
L
E
G
E
H
E
S
E
L
A
L
Dog
Lupus familis
XP_536069
769
88595
G460
E
L
E
S
E
L
E
G
E
Q
E
A
D
P
E
Cat
Felis silvestris
Mouse
Mus musculus
Q8K3R3
807
92676
A466
E
G
P
D
L
D
P
A
S
P
E
L
D
T
Q
Rat
Rattus norvegicus
Q62711
772
88948
G457
E
E
L
E
K
D
E
G
S
D
L
D
P
A
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514368
738
83813
E443
D
A
A
Y
V
S
D
E
D
E
A
A
E
M
E
Chicken
Gallus gallus
Q2VRL0
637
72514
E355
G
S
S
K
R
K
S
E
G
R
S
S
P
P
P
Frog
Xenopus laevis
Q32NH8
758
87399
S456
D
D
S
L
G
E
V
S
D
E
E
E
N
I
E
Zebra Danio
Brachydanio rerio
A5D6R3
784
89362
E480
F
T
N
S
S
D
E
E
S
V
A
G
G
N
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P13217
1095
124845
A498
D
D
D
P
E
E
D
A
S
A
G
K
P
P
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001008790
753
85559
A465
V
S
D
E
D
E
A
A
D
I
D
T
E
D
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LY51
584
66443
D302
G
D
D
D
D
D
D
D
D
D
D
D
D
D
D
Baker's Yeast
Sacchar. cerevisiae
P32383
869
100529
K554
N
E
Q
E
L
R
M
K
D
D
S
T
N
S
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
92.9
84.4
N.A.
71.8
72.6
N.A.
46.7
37.7
59.9
45
N.A.
25.1
N.A.
N.A.
41.3
Protein Similarity:
100
99.7
94.4
91
N.A.
81.4
84.4
N.A.
62.5
54.4
77.9
65.4
N.A.
39.6
N.A.
N.A.
58.7
P-Site Identity:
100
100
26.6
13.3
N.A.
26.6
20
N.A.
13.3
0
13.3
13.3
N.A.
6.6
N.A.
N.A.
20
P-Site Similarity:
100
100
40
26.6
N.A.
60
33.3
N.A.
40
20
33.3
40
N.A.
33.3
N.A.
N.A.
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.3
24.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
40.2
43.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
15
8
8
0
0
0
8
22
0
8
29
15
0
15
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
22
22
22
15
15
29
22
8
36
22
15
15
22
15
8
% D
% Glu:
22
36
8
36
15
43
36
29
22
22
22
15
29
0
29
% E
% Phe:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
15
8
0
8
8
0
8
15
8
0
8
8
8
0
0
% G
% His:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
8
0
0
0
8
0
% I
% Lys:
0
0
0
8
8
8
0
8
0
0
0
8
0
0
8
% K
% Leu:
0
8
8
8
36
8
0
0
0
15
8
22
8
0
8
% L
% Met:
0
0
0
0
0
0
8
0
0
0
0
0
0
8
0
% M
% Asn:
8
0
8
0
0
0
0
0
0
0
0
0
15
8
0
% N
% Pro:
0
0
29
8
0
0
8
0
0
8
0
0
22
22
15
% P
% Gln:
0
0
8
0
0
0
0
0
0
8
0
0
0
0
22
% Q
% Arg:
0
0
0
0
8
8
0
0
0
8
0
0
0
0
0
% R
% Ser:
0
15
15
15
8
8
8
22
29
0
22
8
0
22
15
% S
% Thr:
0
8
0
0
0
0
0
0
0
0
0
15
0
8
0
% T
% Val:
15
0
0
0
8
0
8
0
0
8
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _