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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SH2D3A
All Species:
8.18
Human Site:
T178
Identified Species:
20
UniProt:
Q9BRG2
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9BRG2
NP_005481.2
576
63093
T178
P
I
S
A
L
P
R
T
S
S
D
P
V
L
L
Chimpanzee
Pan troglodytes
XP_524075
576
63049
T178
P
I
S
A
L
P
R
T
S
S
D
P
V
L
L
Rhesus Macaque
Macaca mulatta
XP_001092391
452
49308
T161
I
S
F
C
P
P
D
T
P
S
C
L
L
G
P
Dog
Lupus familis
XP_542135
576
62594
M178
P
T
C
A
L
P
R
M
G
S
D
P
V
L
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9QZK2
820
92245
P367
V
F
R
T
G
S
E
P
T
L
S
P
A
L
V
Rat
Rattus norvegicus
NP_001101192
825
92459
P372
V
F
R
T
G
S
E
P
T
L
S
P
A
L
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520958
765
83358
A295
R
D
A
I
R
N
C
A
L
S
M
D
Q
I
Q
Chicken
Gallus gallus
XP_422334
1050
117784
P600
A
F
R
T
G
S
E
P
S
L
S
P
T
V
V
Frog
Xenopus laevis
Q6INP9
806
92220
T365
P
K
P
H
V
F
R
T
G
S
E
P
T
L
S
Zebra Danio
Brachydanio rerio
NP_001107092
841
94612
P374
V
F
R
T
G
S
E
P
A
L
S
P
T
V
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
73.6
80.9
N.A.
30.8
30.7
N.A.
28.8
24.9
29.1
30.6
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.6
75.3
86.9
N.A.
44.7
44.2
N.A.
42.4
36.8
43.4
44.1
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
20
73.3
N.A.
13.3
13.3
N.A.
6.6
13.3
40
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
26.6
73.3
N.A.
26.6
26.6
N.A.
20
26.6
53.3
20
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
10
30
0
0
0
10
10
0
0
0
20
0
0
% A
% Cys:
0
0
10
10
0
0
10
0
0
0
10
0
0
0
0
% C
% Asp:
0
10
0
0
0
0
10
0
0
0
30
10
0
0
0
% D
% Glu:
0
0
0
0
0
0
40
0
0
0
10
0
0
0
0
% E
% Phe:
0
40
10
0
0
10
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
40
0
0
0
20
0
0
0
0
10
0
% G
% His:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
10
20
0
10
0
0
0
0
0
0
0
0
0
10
0
% I
% Lys:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
30
0
0
0
10
40
0
10
10
60
30
% L
% Met:
0
0
0
0
0
0
0
10
0
0
10
0
0
0
0
% M
% Asn:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% N
% Pro:
40
0
10
0
10
40
0
40
10
0
0
80
0
0
20
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
10
% Q
% Arg:
10
0
40
0
10
0
40
0
0
0
0
0
0
0
0
% R
% Ser:
0
10
20
0
0
40
0
0
30
60
40
0
0
0
10
% S
% Thr:
0
10
0
40
0
0
0
40
20
0
0
0
30
0
0
% T
% Val:
30
0
0
0
10
0
0
0
0
0
0
0
30
20
30
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _