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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: GINS4 All Species: 24.85
Human Site: S12 Identified Species: 39.05
UniProt: Q9BRT9 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9BRT9 NP_115712.1 223 26047 S12 V D F L G Q D S D G G S E E V
Chimpanzee Pan troglodytes XP_001138293 223 26042 S12 L D F L G Q D S D G G S E E V
Rhesus Macaque Macaca mulatta XP_001094432 223 26084 S12 L D F L G Q D S D G G S E E V
Dog Lupus familis XP_539958 292 33552 S80 L D H T G Q D S D A D S E E V
Cat Felis silvestris
Mouse Mus musculus Q99LZ3 223 25942 S12 L D L H G Q D S D G G S E E M
Rat Rattus norvegicus Q499W2 223 26043 S12 Q D L H G Q D S D E G S E E V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510297 388 43006 A177 L V E Q D S R A G S E E D E V
Chicken Gallus gallus XP_001234216 246 28024 S35 A G G E E P D S D D G S E E L
Frog Xenopus laevis NP_001084702 221 25526 V18 G S D E D E E V L T P A E L I
Zebra Danio Brachydanio rerio NP_001003546 217 25089 E12 S E L S G G E E E L M T P A E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_651457 228 26107 D24 S D G A G L E D E D D D D M E
Honey Bee Apis mellifera XP_001120752 219 25421 S13 A Q L T I E N S D Q E E E E E
Nematode Worm Caenorhab. elegans NP_507905 224 25660 F13 S A T T F L D F D D D E Y D E
Sea Urchin Strong. purpuratus XP_001189789 225 26139 F13 D E S L E N E F S S D E E E V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q03406 294 33929 T32 T Q G S S S T T H R D A N T I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 98.6 68.1 N.A. 87.8 88.7 N.A. 49.4 73.1 71.7 71.3 N.A. 40.3 43.9 33.9 56.8
Protein Similarity: 100 100 99.5 72.2 N.A. 93.7 93.7 N.A. 54.3 83.7 84.7 88.7 N.A. 64.4 68.1 58.9 74.6
P-Site Identity: 100 93.3 93.3 66.6 N.A. 73.3 73.3 N.A. 13.3 46.6 6.6 6.6 N.A. 13.3 26.6 13.3 26.6
P-Site Similarity: 100 100 100 73.3 N.A. 86.6 73.3 N.A. 33.3 53.3 33.3 33.3 N.A. 33.3 40 20 40
Percent
Protein Identity: N.A. N.A. N.A. N.A. 24.1 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 44.2 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 14 7 0 7 0 0 0 7 0 7 0 14 0 7 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 7 47 7 0 14 0 54 7 60 20 34 7 14 7 0 % D
% Glu: 0 14 7 14 14 14 27 7 14 7 14 27 67 67 27 % E
% Phe: 0 0 20 0 7 0 0 14 0 0 0 0 0 0 0 % F
% Gly: 7 7 20 0 54 7 0 0 7 27 40 0 0 0 0 % G
% His: 0 0 7 14 0 0 0 0 7 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 14 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 34 0 27 27 0 14 0 0 7 7 0 0 0 7 7 % L
% Met: 0 0 0 0 0 0 0 0 0 0 7 0 0 7 7 % M
% Asn: 0 0 0 0 0 7 7 0 0 0 0 0 7 0 0 % N
% Pro: 0 0 0 0 0 7 0 0 0 0 7 0 7 0 0 % P
% Gln: 7 14 0 7 0 40 0 0 0 7 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 7 0 0 7 0 0 0 0 0 % R
% Ser: 20 7 7 14 7 14 0 54 7 14 0 47 0 0 0 % S
% Thr: 7 0 7 20 0 0 7 7 0 7 0 7 0 7 0 % T
% Val: 7 7 0 0 0 0 0 7 0 0 0 0 0 0 47 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _