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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CCM2
All Species:
26.06
Human Site:
S181
Identified Species:
63.7
UniProt:
Q9BSQ5
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9BSQ5
NP_001025006.1
444
48837
S181
S
R
G
L
S
A
G
S
L
S
E
S
A
V
G
Chimpanzee
Pan troglodytes
XP_519079
506
55231
S243
S
R
G
L
S
A
G
S
L
S
E
S
A
V
G
Rhesus Macaque
Macaca mulatta
XP_001093409
494
54172
R181
H
E
K
V
T
E
R
R
P
L
H
T
V
V
L
Dog
Lupus familis
XP_849621
453
49933
S181
S
R
G
L
T
T
V
S
L
S
E
S
G
V
G
Cat
Felis silvestris
Mouse
Mus musculus
Q8K2Y9
453
49899
S181
S
R
G
L
S
A
G
S
L
S
E
S
A
V
G
Rat
Rattus norvegicus
NP_001119747
453
49812
S181
S
R
G
L
S
A
G
S
L
S
E
S
A
V
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515997
736
79606
S428
S
K
A
L
T
S
G
S
L
T
S
E
G
G
A
Chicken
Gallus gallus
XP_418517
453
50159
S181
S
K
A
L
T
S
G
S
L
S
E
S
G
V
V
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q6DRP4
455
49808
S182
S
P
T
L
S
S
L
S
E
S
G
A
V
L
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_782496
338
38111
A84
N
E
T
S
L
V
R
A
F
I
H
N
I
V
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
87.3
50
89.6
N.A.
92.7
92.7
N.A.
41.2
84.7
N.A.
74.9
N.A.
N.A.
N.A.
N.A.
26.5
Protein Similarity:
100
87.5
58.5
93.8
N.A.
95.5
95.8
N.A.
48.3
91.3
N.A.
83.9
N.A.
N.A.
N.A.
N.A.
45.7
P-Site Identity:
100
100
6.6
73.3
N.A.
100
100
N.A.
33.3
60
N.A.
33.3
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
100
26.6
80
N.A.
100
100
N.A.
60
80
N.A.
53.3
N.A.
N.A.
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
20
0
0
40
0
10
0
0
0
10
40
0
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
20
0
0
0
10
0
0
10
0
60
10
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% F
% Gly:
0
0
50
0
0
0
60
0
0
0
10
0
30
10
50
% G
% His:
10
0
0
0
0
0
0
0
0
0
20
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
10
0
0
10
0
0
% I
% Lys:
0
20
10
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
80
10
0
10
0
70
10
0
0
0
10
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
10
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% N
% Pro:
0
10
0
0
0
0
0
0
10
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
50
0
0
0
0
20
10
0
0
0
0
0
0
0
% R
% Ser:
80
0
0
10
50
30
0
80
0
70
10
60
0
0
10
% S
% Thr:
0
0
20
0
40
10
0
0
0
10
0
10
0
0
0
% T
% Val:
0
0
0
10
0
10
10
0
0
0
0
0
20
80
20
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _