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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: COPS4 All Species: 30
Human Site: S112 Identified Species: 38.82
UniProt: Q9BT78 Number Species: 17
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9BT78 NP_057213.2 406 46269 S112 S I R Q H L A S I Y E K E E D
Chimpanzee Pan troglodytes XP_001136883 398 45560 S104 S I R Q H L A S I Y E K E E D
Rhesus Macaque Macaca mulatta XP_001082657 355 40767 Q87 P L E T G Q K Q Y N V D Y K L
Dog Lupus familis XP_859288 395 45114 I106 F E E Q V A S I R Q H L A S I
Cat Felis silvestris
Mouse Mus musculus O88544 406 46266 S112 S I R Q H L A S I Y E K E E D
Rat Rattus norvegicus Q68FS2 406 46271 S112 S I R Q R L A S I Y E K E E D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507527 188 21373
Chicken Gallus gallus NP_001006447 411 46767 S117 S I R Q H L A S I Y E K E E D
Frog Xenopus laevis NP_001091298 406 46331 S112 S I R Q H L A S I Y E K E E D
Zebra Danio Brachydanio rerio Q6P0H6 406 46327 T112 S I R Q H L A T I Y E K Q E D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9V345 407 46455 N119 G I R F H L A N I Y E R N Q Q
Honey Bee Apis mellifera XP_623684 418 48124 K115 S I R Q H L A K I Y E R N Q N
Nematode Worm Caenorhab. elegans Q9N359 412 46114 S119 I L R L M L A S L Y E K E G R
Sea Urchin Strong. purpuratus XP_791860 354 40869 K86 I P L E T G Q K Q Y Q V D Y K
Poplar Tree Populus trichocarpa XP_002320585 397 45327 E104 I I R E K L A E L Y E S E Q Q
Maize Zea mays NP_001131365 399 45155 E106 V I R E K L A E L Y E S E Q Q
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8L5U0 397 44939 G104 V I R E K L A G L Y E S E Q E
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q7S0P8 440 47908 A129 I Y E E L L A A A H E S Q N S
Conservation
Percent
Protein Identity: 100 95.3 87.4 97 N.A. 99.5 99 N.A. 45 97.8 95.5 94.5 N.A. 70.5 76.5 35.1 68.7
Protein Similarity: 100 96 87.4 97.2 N.A. 99.7 99.5 N.A. 46 98.7 98 97.5 N.A. 82.5 85.1 56 77
P-Site Identity: 100 100 0 6.6 N.A. 100 93.3 N.A. 0 100 100 86.6 N.A. 53.3 66.6 53.3 6.6
P-Site Similarity: 100 100 13.3 13.3 N.A. 100 93.3 N.A. 0 100 100 100 N.A. 73.3 86.6 66.6 26.6
Percent
Protein Identity: 49 48.5 N.A. 48.7 N.A. 35.9
Protein Similarity: 67.4 64.7 N.A. 66 N.A. 56.5
P-Site Identity: 46.6 46.6 N.A. 46.6 N.A. 20
P-Site Similarity: 66.6 66.6 N.A. 73.3 N.A. 46.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 6 78 6 6 0 0 0 6 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 6 6 0 39 % D
% Glu: 0 6 17 28 0 0 0 12 0 0 78 0 56 39 6 % E
% Phe: 6 0 0 6 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 6 0 0 0 6 6 0 6 0 0 0 0 0 6 0 % G
% His: 0 0 0 0 45 0 0 0 0 6 6 0 0 0 0 % H
% Ile: 23 67 0 0 0 0 0 6 50 0 0 0 0 0 6 % I
% Lys: 0 0 0 0 17 0 6 12 0 0 0 45 0 6 6 % K
% Leu: 0 12 6 6 6 78 0 0 23 0 0 6 0 0 6 % L
% Met: 0 0 0 0 6 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 6 0 6 0 0 12 6 6 % N
% Pro: 6 6 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 50 0 6 6 6 6 6 6 0 12 28 17 % Q
% Arg: 0 0 73 0 6 0 0 0 6 0 0 12 0 0 6 % R
% Ser: 45 0 0 0 0 0 6 39 0 0 0 23 0 6 6 % S
% Thr: 0 0 0 6 6 0 0 6 0 0 0 0 0 0 0 % T
% Val: 12 0 0 0 6 0 0 0 0 0 6 6 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 6 0 0 0 0 0 0 6 78 0 0 6 6 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _