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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: COPS4 All Species: 34.24
Human Site: S18 Identified Species: 44.31
UniProt: Q9BT78 Number Species: 17
    Phosphosite Substitution
    Charge Score: 0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9BT78 NP_057213.2 406 46269 S18 Q L M N S S G S H K D L A G K
Chimpanzee Pan troglodytes XP_001136883 398 45560 S13 V L Q A V V N S I K H R Y R Q
Rhesus Macaque Macaca mulatta XP_001082657 355 40767
Dog Lupus familis XP_859288 395 45114 S18 Q L M N S S G S H K D L A G K
Cat Felis silvestris
Mouse Mus musculus O88544 406 46266 S18 Q L M N S S G S H K D L A G K
Rat Rattus norvegicus Q68FS2 406 46271 S18 Q L M N S S G S H K D L A G K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507527 188 21373
Chicken Gallus gallus NP_001006447 411 46767 S23 Q L M N S S G S H K D L A G K
Frog Xenopus laevis NP_001091298 406 46331 S18 Q L M N S S G S H K D L A G K
Zebra Danio Brachydanio rerio Q6P0H6 406 46327 S18 Q L M N S S G S H K D L A G K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9V345 407 46455 T25 G L I N F T G T H K D Q A D K
Honey Bee Apis mellifera XP_623684 418 48124 S21 N L A Y C G G S H K D Q A E K
Nematode Worm Caenorhab. elegans Q9N359 412 46114 D20 V I F A Q D T D H K A Q Y E A
Sea Urchin Strong. purpuratus XP_791860 354 40869
Poplar Tree Populus trichocarpa XP_002320585 397 45327 D13 A S A S T I T D Q R Q K I E Q
Maize Zea mays NP_001131365 399 45155 A12 L A S A A A I A D Q R Q K I E
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8L5U0 397 44939 D13 T N A S A I G D Q R Q K I E Q
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q7S0P8 440 47908 A19 Q V P N W S Q A D R P A A F R
Conservation
Percent
Protein Identity: 100 95.3 87.4 97 N.A. 99.5 99 N.A. 45 97.8 95.5 94.5 N.A. 70.5 76.5 35.1 68.7
Protein Similarity: 100 96 87.4 97.2 N.A. 99.7 99.5 N.A. 46 98.7 98 97.5 N.A. 82.5 85.1 56 77
P-Site Identity: 100 20 0 100 N.A. 100 100 N.A. 0 100 100 100 N.A. 53.3 53.3 13.3 0
P-Site Similarity: 100 26.6 0 100 N.A. 100 100 N.A. 0 100 100 100 N.A. 73.3 53.3 20 0
Percent
Protein Identity: 49 48.5 N.A. 48.7 N.A. 35.9
Protein Similarity: 67.4 64.7 N.A. 66 N.A. 56.5
P-Site Identity: 0 0 N.A. 6.6 N.A. 26.6
P-Site Similarity: 26.6 33.3 N.A. 33.3 N.A. 53.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 6 6 17 17 12 6 0 12 0 0 6 6 56 0 6 % A
% Cys: 0 0 0 0 6 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 6 0 17 12 0 50 0 0 6 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 23 6 % E
% Phe: 0 0 6 0 6 0 0 0 0 0 0 0 0 6 0 % F
% Gly: 6 0 0 0 0 6 56 0 0 0 0 0 0 39 0 % G
% His: 0 0 0 0 0 0 0 0 56 0 6 0 0 0 0 % H
% Ile: 0 6 6 0 0 12 6 0 6 0 0 0 12 6 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 62 0 12 6 0 50 % K
% Leu: 6 56 0 0 0 0 0 0 0 0 0 39 0 0 0 % L
% Met: 0 0 39 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 6 6 0 50 0 0 6 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 6 0 0 0 0 0 0 0 6 0 0 0 0 % P
% Gln: 45 0 6 0 6 0 6 0 12 6 12 23 0 0 17 % Q
% Arg: 0 0 0 0 0 0 0 0 0 17 6 6 0 6 6 % R
% Ser: 0 6 6 12 39 45 0 50 0 0 0 0 0 0 0 % S
% Thr: 6 0 0 0 6 6 12 6 0 0 0 0 0 0 0 % T
% Val: 12 6 0 0 6 6 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 6 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 6 0 0 0 0 0 0 0 0 12 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _