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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TMEM48 All Species: 13.64
Human Site: S395 Identified Species: 30
UniProt: Q9BTX1 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9BTX1 NP_060557.2 674 76305 S395 A T N G R V S S S Y P V E P K
Chimpanzee Pan troglodytes XP_513417 776 87618 S497 A A N G R V S S S Y P V E P K
Rhesus Macaque Macaca mulatta XP_001091911 530 59703 D259 E Q V H R P L D T V S G L L N
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q8VCB1 673 75391 S396 A T N G R M Y S S Y S V E P K
Rat Rattus norvegicus Q6AXN4 673 75694 S396 A T N G R M Y S S Y S V E P K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518195 431 47121 G158 F C V L L L S G V T L A I S V
Chicken Gallus gallus XP_001235442 684 77153 Q406 A A N G R A K Q Q V G E M K V
Frog Xenopus laevis Q6AX31 660 74320 Q389 R V P S S P K Q I R K S S S S
Zebra Danio Brachydanio rerio Q7SZC5 671 74423 T392 S Q S A S S D T R S A S S S S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VCG4 578 65368 V307 A G L G V F N V Y V V Q C L A
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_784037 756 85199 S484 R P I H E Q Y S G M S P Q R P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 86 76.4 N.A. N.A. 87 86.9 N.A. 20.4 67.8 56.8 53.5 N.A. 22.7 N.A. N.A. 28.1
Protein Similarity: 100 86.2 77.3 N.A. N.A. 92.1 92.5 N.A. 33.5 79.3 72.4 72.2 N.A. 43.4 N.A. N.A. 45.3
P-Site Identity: 100 93.3 6.6 N.A. N.A. 80 80 N.A. 6.6 26.6 0 0 N.A. 13.3 N.A. N.A. 6.6
P-Site Similarity: 100 93.3 13.3 N.A. N.A. 86.6 86.6 N.A. 13.3 26.6 0 20 N.A. 20 N.A. N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 55 19 0 10 0 10 0 0 0 0 10 10 0 0 10 % A
% Cys: 0 10 0 0 0 0 0 0 0 0 0 0 10 0 0 % C
% Asp: 0 0 0 0 0 0 10 10 0 0 0 0 0 0 0 % D
% Glu: 10 0 0 0 10 0 0 0 0 0 0 10 37 0 0 % E
% Phe: 10 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 10 0 55 0 0 0 10 10 0 10 10 0 0 0 % G
% His: 0 0 0 19 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 10 0 0 0 0 0 10 0 0 0 10 0 0 % I
% Lys: 0 0 0 0 0 0 19 0 0 0 10 0 0 10 37 % K
% Leu: 0 0 10 10 10 10 10 0 0 0 10 0 10 19 0 % L
% Met: 0 0 0 0 0 19 0 0 0 10 0 0 10 0 0 % M
% Asn: 0 0 46 0 0 0 10 0 0 0 0 0 0 0 10 % N
% Pro: 0 10 10 0 0 19 0 0 0 0 19 10 0 37 10 % P
% Gln: 0 19 0 0 0 10 0 19 10 0 0 10 10 0 0 % Q
% Arg: 19 0 0 0 55 0 0 0 10 10 0 0 0 10 0 % R
% Ser: 10 0 10 10 19 10 28 46 37 10 37 19 19 28 19 % S
% Thr: 0 28 0 0 0 0 0 10 10 10 0 0 0 0 0 % T
% Val: 0 10 19 0 10 19 0 10 10 28 10 37 0 0 19 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 28 0 10 37 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _