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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TMEM48 All Species: 8.48
Human Site: Y541 Identified Species: 18.67
UniProt: Q9BTX1 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9BTX1 NP_060557.2 674 76305 Y541 S K R V L I M Y F F S K H P E
Chimpanzee Pan troglodytes XP_513417 776 87618 Y643 S K R V L I M Y F F S K H P E
Rhesus Macaque Macaca mulatta XP_001091911 530 59703 N405 P V E P K K L N S P E E T T F
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q8VCB1 673 75391 F542 R V L I M Y F F S K H P E A S
Rat Rattus norvegicus Q6AXN4 673 75694 F542 R V L I M Y F F S K H P E A S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518195 431 47121 E304 R F R R S L A E L L R Q S C G
Chicken Gallus gallus XP_001235442 684 77153 F552 R R V L I M Y F F S K H P E A
Frog Xenopus laevis Q6AX31 660 74320 A535 L F S K H P E A S S Q D V F A
Zebra Danio Brachydanio rerio Q7SZC5 671 74423 Y538 A K R V L I V Y L F N K L P E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VCG4 578 65368 V453 L Q R L L Q R V P G I V Y L F
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_784037 756 85199 F630 L H R I S S T F S K H L K V Q
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 86 76.4 N.A. N.A. 87 86.9 N.A. 20.4 67.8 56.8 53.5 N.A. 22.7 N.A. N.A. 28.1
Protein Similarity: 100 86.2 77.3 N.A. N.A. 92.1 92.5 N.A. 33.5 79.3 72.4 72.2 N.A. 43.4 N.A. N.A. 45.3
P-Site Identity: 100 100 0 N.A. N.A. 0 0 N.A. 6.6 6.6 0 66.6 N.A. 13.3 N.A. N.A. 6.6
P-Site Similarity: 100 100 13.3 N.A. N.A. 20 20 N.A. 20 40 0 86.6 N.A. 33.3 N.A. N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 0 0 0 0 0 10 10 0 0 0 0 0 19 19 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 % D
% Glu: 0 0 10 0 0 0 10 10 0 0 10 10 19 10 28 % E
% Phe: 0 19 0 0 0 0 19 37 28 28 0 0 0 10 19 % F
% Gly: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 10 % G
% His: 0 10 0 0 10 0 0 0 0 0 28 10 19 0 0 % H
% Ile: 0 0 0 28 10 28 0 0 0 0 10 0 0 0 0 % I
% Lys: 0 28 0 10 10 10 0 0 0 28 10 28 10 0 0 % K
% Leu: 28 0 19 19 37 10 10 0 19 10 0 10 10 10 0 % L
% Met: 0 0 0 0 19 10 19 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 10 0 0 10 0 0 0 0 % N
% Pro: 10 0 0 10 0 10 0 0 10 10 0 19 10 28 0 % P
% Gln: 0 10 0 0 0 10 0 0 0 0 10 10 0 0 10 % Q
% Arg: 37 10 55 10 0 0 10 0 0 0 10 0 0 0 0 % R
% Ser: 19 0 10 0 19 10 0 0 46 19 19 0 10 0 19 % S
% Thr: 0 0 0 0 0 0 10 0 0 0 0 0 10 10 0 % T
% Val: 0 28 10 28 0 0 10 10 0 0 0 10 10 10 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 19 10 28 0 0 0 0 10 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _