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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DOHH All Species: 41.21
Human Site: Y144 Identified Species: 60.44
UniProt: Q9BU89 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9BU89 NP_001138637.1 302 32904 Y144 G E P A A G P Y L S V D P A P
Chimpanzee Pan troglodytes XP_512268 302 32823 Y144 G E P A A G P Y L S V D P A P
Rhesus Macaque Macaca mulatta XP_001100385 302 32835 Y144 G E P T A G P Y L S V D P A P
Dog Lupus familis XP_542178 303 33106 Y146 P A V A A G P Y L S V D P A P
Cat Felis silvestris
Mouse Mus musculus Q99LN9 302 32887 Y145 E A T C A G P Y L S V D P A P
Rat Rattus norvegicus Q5PPJ4 302 33058 Y145 E A T C A G P Y L S V D P A P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511251 308 33581 Y144 E V P G V N P Y L S V D P A P
Chicken Gallus gallus Q5ZIP3 299 32857 Y144 E E P G S S P Y R S V D P A P
Frog Xenopus laevis Q66KT3 303 33366 Y146 D S P D T N P Y L S V D P A P
Zebra Danio Brachydanio rerio Q7ZUX6 305 33900 Y148 D G T D E N P Y C S V D P A P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9V9U4 302 33546 Y144 K V D D S N P Y A S V D P S P
Honey Bee Apis mellifera XP_394239 303 34154 Y148 I N L Q K S P Y M S V D P A P
Nematode Worm Caenorhab. elegans Q17949 298 33221 Y148 G K D T N S P Y D S V D P T P
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q94JW0 314 34074 F157 S T T E K S P F M S V D P A G
Baker's Yeast Sacchar. cerevisiae P47120 325 36146 Y171 E N L Q Q S L Y S S I D P A P
Red Bread Mold Neurospora crassa Q7S891 324 35309 F155 E K L R Q S D F A S V D P A P
Conservation
Percent
Protein Identity: 100 97.3 97.6 87.4 N.A. 84.7 83.1 N.A. 77.2 74.5 68.9 65.9 N.A. 58.6 58.4 56.2 N.A.
Protein Similarity: 100 98 98.6 94.7 N.A. 92.3 90.4 N.A. 86.3 83.4 79.8 77.6 N.A. 73.5 72.6 70.5 N.A.
P-Site Identity: 100 100 93.3 80 N.A. 73.3 73.3 N.A. 66.6 66.6 66.6 53.3 N.A. 46.6 53.3 53.3 N.A.
P-Site Similarity: 100 100 93.3 80 N.A. 73.3 73.3 N.A. 66.6 73.3 66.6 53.3 N.A. 60 60 60 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 47.4 46.4 45.3
Protein Similarity: N.A. N.A. N.A. 61.4 59 60.1
P-Site Identity: N.A. N.A. N.A. 40 40 40
P-Site Similarity: N.A. N.A. N.A. 53.3 46.6 53.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 19 0 19 38 0 0 0 13 0 0 0 0 88 0 % A
% Cys: 0 0 0 13 0 0 0 0 7 0 0 0 0 0 0 % C
% Asp: 13 0 13 19 0 0 7 0 7 0 0 100 0 0 0 % D
% Glu: 38 25 0 7 7 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 13 0 0 0 0 0 0 0 % F
% Gly: 25 7 0 13 0 38 0 0 0 0 0 0 0 0 7 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 7 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % I
% Lys: 7 13 0 0 13 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 19 0 0 0 7 0 50 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 13 0 0 0 0 0 0 % M
% Asn: 0 13 0 0 7 25 0 0 0 0 0 0 0 0 0 % N
% Pro: 7 0 38 0 0 0 88 0 0 0 0 0 100 0 94 % P
% Gln: 0 0 0 13 13 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 7 0 0 0 0 7 0 0 0 0 0 0 % R
% Ser: 7 7 0 0 13 38 0 0 7 100 0 0 0 7 0 % S
% Thr: 0 7 25 13 7 0 0 0 0 0 0 0 0 7 0 % T
% Val: 0 13 7 0 7 0 0 0 0 0 94 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 88 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _